不同温度二氧化碳气腹对兔体温、红细胞流变性和微循环的影响  

Influence of carbon dioxide pneumoperitoneum at different temperature on body temperature,rheology of red blood cells and microcirculation in rabbits

作　　者：叶占勇[1] 李军[1] 刘合年[1] 巩固[1] 白树荣[1] 

机构地区：[1]成都军区总医院麻醉科,四川成都610083

出　　处：《西部医学》2010年第10期1796-1798,共3页Medical Journal of West China

基　　金：成都军区医学科研"十一五"计划课题(编号:MB07011)

摘　　要：目的研究不同温度二氧化碳气腹对兔体温、红细胞流变性和微循环的影响。方法 18只雌性健康兔按气腹时二氧化碳温度随机均分为两组:等体温组(I组,二氧化碳加温至37℃)和低体温组(H组,二氧化碳温度为21℃)。每组均接受气腹1h。在二氧化碳气腹前(T0)、气腹后30 min(T1)、气腹后60min(T2)测定红细胞流变性。监测心率(HR)、平均动脉压(MAP)、体温、耳廓微循环的血流量和血流速率并记录在相应时点的上述参数值。结果在等体温组,气腹后30 min、60min与气腹前比较,体温变化不大,HR、MAP、红细胞刚性指数和聚集指数显著增加(P<0.05),红细胞变形指数、微循环的血流量和血流速率显著下降(P<0.05);在低体温组,体温下降(P<0.05),其余指标变化更为显著(P<0.01)。红细胞压积气腹前后无明显变化。结论低温二氧化碳气腹可使机体体温下降;等体温和低体温二氧化碳气腹可导致红细胞流变性减弱、微循环的血流量和血流速率下降,但后者的影响更为明显。Objective To study the influence of carbon dioxide pneumoperitoneum at different temperatures on body temperature,rheology of red blood cells（RBC） and microcirculation in rabbits.Methods 18 female healthy rabbits weighing 2.2kg to 3.5kg were randomly divided into two groups based on temperature of CO2： isothermic group（group I,37℃） and hypothermia group（group H,21℃）.The animals were treated with 1h pneumoperitoneum at different temperatures.Blood samples were taken before CO2 pneumoperitoneum,at 30 and 60minutes after pneumoperitoneum for detecting the indexes of rheology of RBC.Body temperature（T）,hemodynamics including heart rate（HR）,mean arterial pressure（MAP） and the volume and velocity of the microcirculation of auricle were monitored.Results 30 and 60 minutes after CO2 pneumoperitoneum,HR,MAP,the aggregation and rigid indexes of RBC were significantly raised（P〈0.05）,the deformobility indexes of RBC and the volume and velocity of the microcirculation were markedly decreased（P〈0.05）.Conclusion After hypothermia carbon dioxide pneumoperitoneum body temperature may be decreased.After isothermic and hypothermia pneumoperitoneum,rheology of RBC and the volume and velocity of the microcirculation may be decreased.

关 键 词：不同温度 二氧化碳气腹 体温 红细胞流变性 微循环 

分 类 号：R331[医药卫生—人体生理学]