解脲脲原体、抗心磷脂抗体与反复自然流产间关系的研究  

Study of the relationship among ureaplasma urealyticum,anticardiolipin antibody and recurrent spontaneous abortion

作　　者：张磊[1] 刘瑾[2] 赵晓岚[2] 

机构地区：[1]浙江省杭州市第一人民医院妇产科,310006 [2]西安交通大学医学院第二附属医院妇产科

出　　处：《中国妇幼保健》2010年第29期4270-4271,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨反复自然流产(RSA)与解脲脲原体(Uu)感染、抗心磷脂抗体(ACA)间的关系,并进一步研究解脲脲原体感染与抗心磷脂抗体产生间的关系。方法:应用酶联免疫吸附试验(ELISA)法检测126例反复自然流产患者(RSA组)静脉血中ACAIgM、IgG含量;采用荧光定量PCR法检测其宫颈分泌物中解脲脲原体含量;50例孕前咨询查体者(PE组)作为对照组并进行相应检测。结果:126例反复自然流产患者的ACAIgM、IgG,Uu阳性率分别为21.43%、30.16%、32.54%,显著高于对照组对应的4.00%、4.00%、12.00%(P<0.05)。RSA中解脲脲原体阳性组ACAIgM、IgG阳性率分别为36.59%、51.22%,显著高于阴性组的14.12%、20.00%(P<0.05)。结论:解脲脲原体感染、抗心磷脂抗体是导致反复自然流产的重要因素,且抗心磷脂抗体的产生与解脲脲原体感染具有相关性。Objective：To explore the relationship among recurrent spontaneous abortion （RSA）,ureaplasma urealyticum （Uu） and anticardiolipin antibody （ACA）,and further study the relationship between Uu infection and ACA production.Methods：Enzyme linked immunosorbent assay （ELISA） was applied to detect the levels of ACA IgM and IgG in serum of 126 cases with RSA;the level of Uu in cervical secretion was detected by fluorescence quantitative polymerase chain reaction （FQ-PCR） ;50 cases with preconceptional counseling and examination were selected as control group.Results：The positive rates of ACA IgM,IgG and Uu in RSA group were 21.43%,30.16% and 32.54%,respectively,which were significantly higher than those in control group （4.00%,4.00% and 12.00%） （P 0.05） ;in RSA group,the positive rates of ACA IgM and IgG in Uu infection group were 36.59% and 51.22%,respectively,which were significantly higher than those in non-Uu infection group （14.12% and 20.00%） （P 0.05）.Conclusion：Uu infection and ACA are important factors leading to RSA,and there is a correlation between ACA production and Uu infection.

关 键 词：解脲脲原体 抗心磷脂抗体 反复自然流产 

分 类 号：R714.21[医药卫生—妇产科学]