细胞核相关抗原、血管内皮生长因子与子宫腺肌症发生发展的相关性  

The relationship of Ki67 and VEGF in adenomyosis uterus

作　　者：胡树红[1] 廖谦和[2] 陈利琼[1] 吴文珍[2] 夏康[2] 

机构地区：[1]温州医学院附属第三医院妇产科,浙江瑞安325200 [2]温州医学院附属第三医院病理科

出　　处：《中国妇幼保健》2010年第27期3862-3863,共2页Maternal and Child Health Care of China

基　　金：浙江省瑞安市科技局科技计划资助项目〔项目编号:20072187〕

摘　　要：目的:探讨细胞核增殖抗原(Ki67)及血管内皮生长因子(VEGF)在子宫腺肌症中在位和异位内膜的表达及意义。方法:用免疫组化EnVision法检测30例子宫腺肌症在位子宫内膜和肌间异位内膜Ki67和VEGF的表达情况。结果:Ki67和VEGF在子宫腺肌症病变中均有不同程度的阳性表达,子宫肌层异位内膜Ki67阳性表达率为53.3%,VEGF阳性表达率为96.7%。异位内膜的腺上皮Ki67和VEGF表达高于在位内膜的腺上皮(P<0.05)。腺上皮表达高于间质(P<0.05)。月经周期中VEGF的表达差异无统计学意义(P>0.05)。异位内膜腺体VEGF和Ki67的表达具有相关性(P<0.01)。结论:子宫腺肌症是一种细胞增殖性疾病。子宫腺肌症异位和在位子宫内膜组织中均有Ki67和VEGF的阳性表达,与子宫腺肌症的临床症状可能有关。Objective：To investigate the expressions of Ki67 and VEGF in the pathogenesis of adenomyosis uterus.Methods：The expressions of Ki67 and VEGF in 30 cases of adenomyosis uterus were detected by immunohistochemical EnVision method.Results：The positive rates of Ki67 and VEGF in ectopic endometrium of myometrium were 53.3% and 96.7%, respectively.The expressions of Ki67 and VEGF increased significantly in ectopic endometrium were slightly than those in eutopic endometrium（P〈0.05）.The strong positive rate in the eutopic endometrium was significantly higher than that in the stroma cells（P〈0.05）.In adenomyosis, no significant changes of VEGF expression was found throughout the menstrual cycle（P〉0.05）.The expression of VEGF had a positive correlation with the expression of Ki67（P〈0.01）.Conclusion：Adenomyosis is an endometrial proliferative disease.Ki67 and VEGF all express in the ectopic and eutopic endometrium. They may be play an important roles in clinical symptoms of adenomyosis.

关 键 词：子宫腺肌症 细胞核增殖抗原 血管内皮生长因子 免疫组织化学 

分 类 号：R711.74[医药卫生—妇产科学]