2型糖尿病患者尿微量白蛋白排泄率与外周血管病变及感觉阈值关系的研究  

Associations of urine albumin excretion rate with peripheral vascular disease and perceptive threshold in patients with type 2 diabetes

作　　者：陈燕[1] 顾刘宝[1] 陈玲[1] 丁林锋[2] 卞茸文[1] 

机构地区：[1]江苏省老年医院内分泌科,江苏省南京市210024 [2]江苏省老年医院心内科,江苏省南京市210024

出　　处：《实用老年医学》2010年第5期390-392,共3页Practical Geriatrics

基　　金：江苏省卫生厅重大课题资助项目(H200931)

摘　　要：目的探讨2型糖尿病患者尿微量白蛋白排泄率与外周血管病变及感觉阈值之间的关系。方法选择2型糖尿病患者141例按尿微量白蛋白排泄/肌酐浓度率分为2个观察组:≤30mg/g者为A组,>30mg/g者为B组,比较2组颈动脉内中膜厚度(IMT)、外周血管的踝肱比(ABI)及震动感觉阈值(VPT)的变化,以及体质量指数(BMI)、血压、血糖、糖化血红蛋白、血脂水平、病史等方面的差异。结果 2组间颈动脉IMT及外周血管病变与微量白蛋白排泄率成正相关(P<0.05);logistic多元回归分析发现,糖尿病病程、高血压、低密度脂蛋白胆固醇、空腹血糖是尿微量白蛋白排泄的危险因素。2组间VPT无显著差异(P>0.05)。结论颈动脉IMT及外周血管病变与微量白蛋白排泄相关,颈动脉IMT增厚早于下肢血管病变。Objective To investigate the associations of urine albumin excretion rate with peripheral vascular di-sease and perceptive threshold in patients with type 2 diabetes.Methods A total of 141 patients with type 2 diabetes were divided into two groups according to the ratio of urine albumin excretion/creatinine （UAE/Cr）.The patients in group A had UAE/Cr≤30 mg/g and the patients in group B had UAE/Cr 30 mg/g.The carotid intima-media thickness （IMT）,ankle brachial index （ABI）,the change of perceptive threshold,body mass index （BMI）,blood pressure,blood glucose,glycosylated hemoglobin,blood lipid and history were compared between groups.Results IMT and peripheral vascular disease were positively correlated with urine albumin excretion rate （P0.05）.Logistic regression revealed that history of diabetes,high blood pressure,low density lipoprotein cholesterol and fasting blood glucose were risk factors for urine albumin excretion.There was no significant difference in perceptive threshold between the two groups （P0.05）.Conclusions IMT and peripheral vascular disease are associated with urine albumin excretion.IMT happens before lower-extremity arterial disease.

关 键 词：2型糖尿病 尿微量白蛋白 外周血管病变 感觉阈值 

分 类 号：R587.1[医药卫生—内分泌]