人血白蛋白对老年多器官功能障碍伴低蛋白血症病人的影响  

Influences of human albumin on hypoalbuminemia in the elderly with multiple organ dysfunction syndrome

作　　者：李太勇[1] 李曙平[1] 姜辉[1] 方烨[1] 

机构地区：[1]中国人民解放军广州军区武汉总医院干部病房一科,湖北省武汉市430070

出　　处：《实用老年医学》2010年第5期405-407,共3页Practical Geriatrics

摘　　要：目的探讨人血白蛋白对伴有低蛋白血症的老年多器官功能不全病人的影响。方法将58例血浆白蛋白<30g/L的老年多器官功能不全患者分为2组。对照组进行常规治疗及营养支持,治疗组在此基础上给予20%的白蛋白治疗。观察2组治疗第1天和第14天时的急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ评分)、序贯器官衰竭功能评分(SOFA评分)及14d时的病死率。结果对照组白蛋白水平不随时间改变,治疗组的白蛋白水平升高明显(P<0.01)。治疗组较对照组的APACHEⅡ评分、SOFA评分有明显的改善(P<0.01)。14d时2组的病死率有统计学差异(P<0.05)。结论白蛋白治疗可以改善伴有低蛋白血症老年危重症患者的器官功能,并降低患者短期病死率。Objective To investigate the effect of human albumin on hypoalbuminemia in elderly patients with multiple organ dysfunction syndrome（MODS）.Methods Fifty-eight elderly MODS patients with serum albumin less than 30 g/L were divided into two groups.The control group received the conventional treatment and nutritional support,and the treatment group received addiontional 20% of albumin treatment.The APACHE Ⅱ scores,SOFA scores at the 1d,14 d after treatment and the mortality at the 14 d in two groups were observed and compared.Results The albumin level of control group was not changed with time,while the albumin level increased significantly in treatment group （P0.01）.The APACHE Ⅱ scores,SOFA scores were significantly improved in treatment group than those in control group （P0.01）.There was significant difference in mortality betweent two groups（P0.05）.Conclusions Albumin treatment can improve organ function and reduce short-term death in elderly MODS patients with hypoalbuminemia.

关 键 词：人血白蛋白 多器官功能不全综合征 老年人 低蛋白血症 

分 类 号：R457[医药卫生—治疗学]