他汀对未合并冠心病的高胆固醇血症患者血管内皮功能的影响  

Effects of simvastatin on the endothelial function in hyperlipidemia patients without coronary artery disease

作　　者：张素敏[1] 王广[1] 曾辉[1] 刘金波[1] 于婕[1] 米琳[1] 毛节明[1] 

机构地区：[1]北京大学第三医院,北京100191

出　　处：《山东医药》2010年第36期7-9,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30770873);中华医学会临床医学科研专项资金资助项目(07060590067);北京大学第三医院中青年骨干基金资助项目(78441-01)

摘　　要：目的探讨辛伐他汀对未合并冠心病的高胆固醇血症患者血管内皮功能及动脉僵硬度的影响。方法 30例高胆固醇血症患者应用辛伐他汀20 mg/d治疗12周,治疗前后分别采集空腹静脉血,通过酶联免疫吸附实验检测血浆一氧化氮(NO)水平;应用动脉硬化测定仪测定肱踝脉搏波传导速度(PWV),评价动脉硬化程度;应用彩色多普勒超声诊断仪测定肱动脉血流速度积分(VTI),评价血管舒张功能。结果辛伐他汀治疗后患者总胆固醇(TC)、低密度脂蛋白胆固醇水平明显降低,PWV水平显著降低,血浆NO、肱动脉VTI值显著高于基线水平。结论辛伐他汀可改善无明确冠心病的高脂血症患者血管内皮功能及动脉硬化程度。Objective To investigate the effects of simvastatin on vascular endothelium function in hyperlipidemia patients without coronary artery disease.Methods Thirty hyperlipidemia patients were treated with simvastatin（20 mg/d）for 12 weeks.Lipid profile was conducted through venenblut translating while fasting in the morning before and after therapy.The plasma was collected before and after simvastatin treatment.NO was detected through enzyme-linked immunosorbent reaction.Atherosclerosis tester was used to detect the pulse wave velocity（PWV） of ankle brachial.Color doppler ultrasound diagnosis with ECG measurements device was applied to calculate brachial velocity-time integral（VTI）.Results Plasma levels of TC,LDL-C were reduced compared with baseline levels.PWV levels were decreased significantly after 12 weeks statin treatment.Plasma level of NO was increased significantly compared with baseline level.Moreover,VTI of brachial artery were increased significantly after simvastatin treatment.Conclusion Endothelial function and arterial stiffness were improved by simvastatin treatment in hyperlipidemia patients without coronary artery disease.

关 键 词：辛伐他汀 高胆固醇血症 冠状动脉疾病 内皮功能 

分 类 号：R541.4[医药卫生—心血管疾病]