泮托拉唑联合克拉霉素、阿莫西林治疗消化性溃疡的疗效观察  

OBSERVATION OF CURATIVE EFFECT ON TREATMENT OF PEPTIC ULCER WITH PANTOPRAZOLE COMBINED CLARITHROMYCIN AND AMOXICILLIN

作　　者：唐维敏[1] 

机构地区：[1]北京市长辛店医院,北京100072

出　　处：《现代预防医学》2010年第19期3798-3799,共2页Modern Preventive Medicine

摘　　要：[目的]探讨泮托拉唑联合克拉霉素、阿莫西林治疗消化性溃疡的的临床疗效。[方法]128例确诊为消化性溃疡的患者,随机分为治疗组和对照组,治疗组患者采用泮托拉唑联合克拉霉素、阿莫西林治疗,对照组应用奥美拉唑联合甲硝唑、阿莫西林治疗,两组疗程均为4周,并比较两组临床疗效和不良反应。[结果]治疗后,治疗组患者的临床总有效率(90.6%)明显高于对照组(71.9%),且痊愈率(70.3%)优于对照组(53.1%),两组比较差异均有统计学意义(P﹤0.05),而两组患者的不良反应发生率无明显差异(P﹥0.05)。[结论]泮托拉唑联合克拉霉素、阿莫西林应用是治疗消化性溃疡的一种安全可靠,疗效明显的治疗方法,值得临床进一步推广应用。[Objective] To investigate the clinical efficacy of treatment for peptic ulcer with joint medication that pantoprazole,clarithromycin and amoxicillin. [Methods] 128 patients diagnosed as peptic ulcer were randomly divided into treatment group and control group,treatment group were treated with pantoprazole combined clarithromycin and amoxicillin. The control group received omeprazole,metronidazole,amoxicillin treatment. Both were treated for 4 weeks,and compared the clinical efficacy and adverse reactions. [Results] After treatment,the total clinical effective rate in treatment group（90.6%） was higher than that in control group（71.9%） ,and the curative rate（70.3%） was also higher than that in control group（53.1%） . Those differences between the two groups were significant（P﹤0.05） ,while the adverse reactions in two groups were not significantly different（P﹥0.05） . [Conclusion] Treatment for peptic ulcer with pantoprazole combined clarithromycin and amoxicillin is a safe and effective treatment obviously,is worthy for further promotion.

关 键 词：泮托拉唑 克拉霉素 阿莫西林 消化性溃疡 

分 类 号：R975.6[医药卫生—药品]