无溶剂条件下α-羟基磷酸酯的合成  

Green Synthesis of α-Hydroxyl Phosphonate under Solvent-Free Condition

作　　者：沈丽丽[1,2] 刘若雨[2] 廖新成[2] 叶勇[2] 

机构地区：[1]河南教育学院化学系,河南郑州450014 [2]郑州大学化学系,河南郑州450001

出　　处：《化学研究》2010年第5期40-43,47,共5页Chemical Research

基　　金：国家自然科学基金资助项目(20602032;20972143)

摘　　要：在无溶剂条件下,以碳酸钾做催化剂,芳香醛与亚磷酸酯在室温下通过研磨,合成了一系列磷酸酯类化合物.该反应条件温和,操作简单,时间短,对环境友好,是一种绿色的合成方法.产物结构经IR,MS,1HNMR等方法表征.A series of α-hydroxyl phosphonate were obtained under solvent-free conditions by grinding the mixture of raw materials aromatic aldehyde and phosphite ester in the presence of potassium carbonate as a catalyst.The products were characterized by means of infrared spectrometry,mass spectrometry,and nuclear magnetic resonance （1H NMR） spectroscopy.Results indicate that the established method can be readily used as a green method to synthesizing α-hydroxyl phosphonate under mild conditions and with easy operation.

关 键 词：α-羟基磷酸酯 Phosphor-Aldol反应 无溶剂有机合成 

分 类 号：O627.5[理学—有机化学]