环磷酰胺+泼尼松治疗狼疮肾炎32例分析  

The study of forward effect in treatment of LN with CTX and prednisone

作　　者：韦宏成[1] 毛晓玲[1] 陈湛华[1] 郑绮宜[1] 叶任高[2] 

机构地区：[1]暨南大学医学院第一附属医院内科,广东广州510630 [2]中山医科大学第一附属医院肾脏病研究所,广东广州510089

出　　处：《暨南大学学报（自然科学与医学版）》1999年第4期48-50,共3页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的：观察延长环磷酰胺冲击治疗狼疮性肾炎的远期疗效。方法：追踪观察３２ 例狼疮性肾炎患者（４８ ±１０） 个月，所有患者在完成常规化疗疗程之后，环磷酰胺再间歇冲击２ 年。结果：治疗后２０ 例完全缓解，１２ 例部分缓解，３６ 个月时持续缓解率达９３７ ％ ，４８ 个月时达８１２ ％ ，至追踪期末为７１２ ％ 。结论：环磷酰胺＋ 泼尼松治疗有较高的缓解率，延长环磷酰胺冲击。Aim:To evaluate the results of long-term prognosis with corticosteroids and cyclophosphamide (CTX) in the treatment of nephritis of systemic lupus erythematosus.Methods:Thirty-two patients with LN were followed up for 48±10 months. Renal biopsies wre preformed in 27/32 of them. The treatment was arranged in 3 phases: 1) puls treatment phase; 2)continuous treatment phase; 3) maintenance treatment phase. Then CTX puls continued to 2 years. Results:After the first immunosuppressive cycle, 20/32 patients achhieved remission of LN and the other parcel remission. After 36 monthes a permanent regression achieved in 93.7%, 48 months in 81.2% and the end of follow up in 71.2%. Conclusion:It was suggested to add a CTX puls every 3 months for 2 years as a booster an achieve excellent long-term results in the treatment of LN.

关 键 词：狼疮性肾炎 肾病综合征 环磷酰胺 泼尼松 治疗 

分 类 号：R593.242[医药卫生—内科学]