肝癌肝移植术后^(18)F-FDG PET/CT显像特点和预后判断  

Imaging of ^(18)F-FDG PET/CT and its value in prediction of prognosis in patients with hepatocellular carcinoma after transplantation

作　　者：李爱梅[1] 郭万华[1] 贾鹏[1] 申景涛[1] 张颖[1] 

机构地区：[1]南京大学医学院附属鼓楼医院核医学科,江苏南京210008

出　　处：《东南国防医药》2010年第5期393-396,共4页Military Medical Journal of Southeast China

基　　金：南京市医学重点科技发展项目(ZKX09019)

摘　　要：目的分析肝癌肝移植患者术后18F-FDG(18氟标记的脱氧葡萄糖)PET/CT的显像特点和预后判断。方法回顾分析2006年以来15例已行肝移植的肝癌患者的临床病历资料和18F-FDG PET/CT的影像学资料及随访结果,用Kaplan-Meier方法计算其生存率,COX回归进行预后因素分析。结果 15例肝移植患者PET/CT显像中,9例提示肿瘤复发和远处转移,6例为阴性显像。②15例显像分为阳性组(n=9)和阴性组(n=6),中位生存时间为分别为18个月和67个月。③Log-rank单因素分析预后因素年龄、最大标准摄取值(SUVmax)和甲胎蛋白(AFP)水平是影响预后的独立因素。结论 18F-FDG PET/CT对肝癌肝移植患者的全面评估及预后判断具有较好的应用价值。Objective To analyze 18F-FDG PET/CT imaging of postransplatation and predict prognosis in patients with hepatocellular carcinoma.Methods Clinical data,18F-FDG PET/CT imaging picture and follow up results of 15 patients who underwent liver transplantation after 2006 were retrospectively analyzed.The cumulative survival was calculated by Kaplan-Meier method.The COX multivariate regression was applied for prognostic factors analysis.Results In 15 patients,tumor recurrence and distant metastases were detected in 9 cases and not detected in 6 cases.The median time of survival was 18 months and 67 months in positive and negative groups.Log-rank analysis showed that the age,SUVmax and alpha protein（AFP）were independent factors for prognosis.Conclusion 18F-FDG PET/CT plays an important role in assessment of postransplatation and prediction of prognosis in patients with hepatocellular cancer.

关 键 词：PET/CT 肝癌 肝移植 评估 

分 类 号：R657.3[医药卫生—外科学] R814.42[医药卫生—临床医学]