胆红素神经毒性相关因素研究  

Study on correlated factors of bilirubin neurotoxicity

作　　者：刘丽娟[1] 朴梅花[1] 李松[1] 

机构地区：[1]北京大学第三医院儿科,100191

出　　处：《中华围产医学杂志》2010年第5期390-393,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的探讨胆红素神经毒性的相关因素。方法以2007年7月至10月在北京大学第三医院住院的53例黄疸新生儿作为研究对象，通过分析脑干听觉诱发电位各波潜伏期、波间期与血清游离胆红素的相关性，筛选反映胆红素神经毒性的敏感指标，并对敏感指标与各种可能的相关因素进行多因素分析。结果（1）控制纠正胎龄后，脑干听觉诱发电位中V波潜伏期与血清游离胆红素呈正相关（r=0．228，P=0．020），其他各波潜伏期和波间期与血清游离胆红素均无相关性。（2）以V波潜伏期为因变量，得到多元线性回归方程：V波潜伏期=9．721—0．082×纠正胎龄＋0．064×胆红素与白蛋白比值＋0．504×酸中毒（F=7．534，P〈0．01）。结论V波潜伏期是反映胆红素神经毒性的敏感指标。胆红素神经毒性与胆红素与白蛋白比值和酸中毒相关。Objective To explore the correlated factors of bilirubin neurotoxicity. Methods From July 2007 to October 2007, 53 hospitalized patients with jaundice in neonatal ward of Peking University Third Hospital were enrolled in the study. The relationship between serum free bilirubin and parameters of brainstem auditory evoked potential（BAEP） was analyzed to screen the sensitive index of biliruhin neurotoxicity. Multivariate analysis was conducted between the sensitive parameter and various factors. Results Partial correlation analysis showed that the wave V latency was positively correlated to serum free bilirubin（r= 0. 228, P= 0. 020） after the corrected gestational age was controlled. There were no correlation between other lateneies or interwave intervals and serum free bilirubin. Linear regression showed the equation was wave V latency= 9. 721- 0. 082 × corrected gestational age＋0. 064× bilirubin/albumin＋0. 504× aeidemia（F= 7. 534, P〈0.01）. Conclusions Wave V latency is the sensitive indicator of bilirubin neurotoxicity, which is correlated with the value of bilirubin/albumin and aeidemia.

关 键 词：黄疸 新生儿 胆红素 诱发电位 听觉 脑干 

分 类 号：R722[医药卫生—儿科]