β2-肾上腺素能受体基因Arg16/Gly多态性与新疆哈萨克族男性甘油三酯水平的关系  

Association of Beta2 Adrenergic Receptor Arg16/Gly Polymorphism with Triglyceride in Male Kazakans of Xinjiang

作　　者：骆秦[1] 李南方[1] 周玲[1] 李涛[1] 王新玲[1] 祖菲亚[1] 张德莲[1] 常桂娟[1] 周克明[1] 洪静[1] 

机构地区：[1]新疆维吾尔自治区人民医院高血压科,新疆维吾尔自治区高血压评断治疗中心,乌鲁木齐830001

出　　处：《科学技术与工程》2010年第28期6979-6982,共4页Science Technology and Engineering

基　　金：新疆维吾尔自治区科技基础条件平台建设项目(编号:PT0903)资助

摘　　要：探讨β2-肾上腺素能受体（β2-adrenergic receptor,β2-AR）基因Arg16/Gly多态性与新疆哈萨克族男性血清甘油三酯（TG）水平的关系。采集新疆阿勒泰地区265例30岁-60岁之间哈萨克族男性牧民的遗传标本,采用聚合酶链反应-限制性酶切片段多态性（PCR-RFLP）技术分析β2-AR基因Arg16/Gly多态性,观察各基因型和等位基因与TC水平的关系。（1）在扣除收缩压、舒张压、BMI和年龄等影响因素后,血清TG水平在β2-AR基因Arg16/Gly多态位点三种基因型间无统计学差异（P〉0.05）。（2）将人群按血清TG水平〈1.7mmol/L、（1.7-2.25）mmol/L、≥2.26mmol/L划分为正常组、边缘升高组及升高组3组,β2-AR基因Arg16/Gly多态位点三种基因型频率在TG正常、边缘升高及升高组3组中的分布无统计学差异（P（0.05）。β2-AR基因Arg16/Gly多态性与哈萨克族男性牧民的TG水平升高无关。To investigate the relationship between β2-AR gene Arg16/Gly polymorphism and serum triglyceride in male Kazakans of Xinjiang.To detect the genotypes of β2-AR gene Arg16/Gly polymorphism by the polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）technique in 265 kazakans with age from 30 to 60,and analyse association of the three genotypes with triglyceride.（1）After deduct factors of blood pressure,age and body mass index,et al,no significant difference were found in level of serum triglyceride between the three genotypes.（2）To divide the subjects into three groups with normal,marginally high and high level of TG according to its level 1.7 mmol/l,（1.7～2.25）mmol/l,≥2.26 mmol.The frequency of both genotypes and alles in the three groups were not found significant difference.No association were found between β2-AR gene Arg16/Gly polymorphism and serum triglyceride in male kazakans of Xinjiang.

关 键 词：β2-肾上腺素受体(β2-AR) Arg16/Gly多态性 甘油三酯 哈萨克族男性 

分 类 号：R335.4[医药卫生—人体生理学]