慢性阻塞性肺疾病相关性肺高压诊断和治疗进展  

Advance in diagnosis and treatment for chronic obstructive pulmonary disease related pulmonary hypertension

作　　者：徐传财[1] 解卫平[1] 

机构地区：[1]南京医科大学第一附属医院呼吸内科,210029

出　　处：《国际呼吸杂志》2010年第19期1184-1188,共5页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病是我国常见的呼吸系统疾病，肺高压是其重要的并发症之一。右心导管检查是诊断肺高压的“金标准”，但临床应用超声心动图更为广泛。目前尚缺乏治疗慢性阻塞性肺疾病相关性肺高压效果较好的药物，长期氧疗可以延缓其病程进展，他汀类和吸入前列环素类颇有疗效，可溶性鸟苷酸环化酶激动剂、吸入一氧化氮和吸入内皮素受体拮抗剂等均是有前景的治疗药物。Chronic obstructive pulmonary disease （COPD） is a common respiratory disease in China. Pulmonary hypertension is an important complication of COPD. Right heart catheterization is ＂gold standard＂ of pulmonary hypertension＇s diagnosis, but echocardiography applied more widely. There is currently lack of better-performing drugs to treat COPD-related pulmonary hypertension. The long-term oxygen therapy can delay progression of COPD-related pulmonary hypertension. Inhaled prostacyclin and statins are more effective. Soluble guanylate cyclase activator,inhalation of endothelin receptor antagonists and nitric oxide are promising treatment.

关 键 词：慢性阻塞性肺疾病 肺高压 前列环索类 内皮素受体拮抗剂 

分 类 号：R563.9[医药卫生—呼吸系统]