葡萄糖转运载体及其在单糖肠吸收中的作用研究进展  

Glucose Transporter and Research Progress on Mechanism of Glycose Absorption in the Intestine

作　　者：周瑞宇[1] 辛现良[2] 耿美玉[1,2] 

机构地区：[1]中国海洋大学医药学院,山东青岛266003 [2]中国科学院上海药物研究所,上海201203

出　　处：《现代生物医学进展》2010年第17期3335-3339,共5页Progress in Modern Biomedicine

基　　金：国家杰出青年科学基金资助(No30725046)

摘　　要：糖类物质是机体的主要能源物质,对机体代谢与内环境稳态有非常重要的作用。葡萄糖作为该类化合物主要的消化尾产物,其吸收主要通过位于肠黏膜上皮细胞的两类葡萄糖转运载体家族来完成。在该吸收过程中,Na+依赖性葡萄糖转运载体1(SGLT-1)和易化性葡萄糖转运载体2、5(Glut-2、Glut-5)发挥了重要的作用。本文综述了肠道不同葡萄糖转运载体家族的成员和分类,并结合葡萄糖肠吸收跨膜转运的机理详细阐述了上述三个载体的分布和影响其功能及表达的因素。Carbohydrate is the main source of energy in organisms and plays a central role in metabolism and cellular homeostasis.Glucose as the main compounds of the digestive end product,its absorption is co-mediated by two families of glucose transporter located in the enterocytes of the intestine.In the absorption process,sodium dependent glucose transporter 1（SGLT-1）and facilitated glucose transporter 2,5（Glut-2,Glut-5）has played an important role.This article reviews the different glucose transporter family members in intestinal and their classification,then described in detail the distribution of these glucose transporter families and the function and the expression regulation by some factors combined with the molecular mechanism of glucose absorption in intestinal.

关 键 词：葡萄糖转运载体 Na^+依赖性葡萄糖转运载体1 易化性葡萄糖转运载体2 易化性葡萄糖转运载体5 

分 类 号：R966[医药卫生—药理学]