腹型肥胖的研究进展  

Recent progress of abdominal obesity

作　　者：韩亭亭[1] 胡耀敏[1] 刘伟[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,200127

出　　处：《国际内分泌代谢杂志》2010年第5期318-320,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30670988）;上海浦东新区社会发展局卫生科技项目（PW2008D-1）

摘　　要：近年来腹型肥胖作为代谢综合征最重要的特征得到了广泛关注。“脂质异位沉积”学说提出腹部皮下脂肪与内脏脂肪一样，在促进胰岛素抵抗形成的过程中发挥关键作用，同时也是导致心血管代谢风险的重要因素，而并非仅表现为既往所认为的机体保护作用。提示无论腹部皮下脂肪还是内脏脂肪堆积引起的腰围增加都应当得到足够的重视，也进一步支持将腰围作为代谢综合征工作定义中肥胖的诊断标准。腹型肥胖的治疗基础仍是生活方式干预，而体液因子、胃肠道激素及棕色脂肪研究的开展为腹型肥胖提供了新的治疗方向。Abdominal obesity, as the most important feature of metabolic syndrome, has received much attention in recent years. More recently,＂ ectopic fat deposition＂ hypothesis has proposed that abdominal subcutaneous adipose which was thought to be protective,as well as visceral adipose, plays a crucial role in promoting the formation process of insulin resistance. And abdominal subcutaneous adipose is an important metabolic risk factor of cardiovascular disease. Thus the increase of waist circumference should be focused on no matter whether it is caused by abdominal subeutaneous or visceral adipose accumulation. And the new hypothesis further supports waist circumference as the diagnostic criteria for obesity in the working definition of metabolic syndrmne. Litestyle interventions are still the basis for the treatment of abdominal obesity, while humoral factors, gastrointestinal hormones, and brown fat provide new therapeutic directions.

关 键 词：腹型肥胖 代谢综合征 内脏脂肪 腹部皮下脂肪 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]