新的脂肪细胞因子与冠心病  

Relationship between new adipocytokines and coronary heart disease

作　　者：高秀莹[1] 陶红[1] 

机构地区：[1]首都医科大学附属北京安贞医院全科医疗科,100029

出　　处：《国际内分泌代谢杂志》2010年第5期343-345,共3页International Journal of Endocrinology and Metabolism

基　　金：首都医科大学基础-临床科研合作课题（10JL54）

摘　　要：脂肪组织可分泌众多的脂肪细胞因子。它们参与体内物质和能量代谢、肥胖、胰岛素抵抗的病理生理过程，其中许多因子还在冠心病的发生、发展中起重要作用。内脂素、血清淀粉样蛋白A（SAA）、apelin、chemerin是近几年来新发现的脂肪细胞因子，研究发现它们与冠心病关系密切，直接或间接参与了动脉粥样硬化的病理生理过程。对这几种因子的深入研究将为冠心病的防治提供新的靶点。Adipose tissue can secret numerous adipokines. They not only participate in material and energy metabolism,pathophysiologic process of obesity and insulin resistance,but also play an important role in the occurrence and development of coronary heart disease. Visfatin, serum amyloid A （SAA） , apelin, chemerin are recently established adipocytokines. Researches have found that they are closely related to coronary heart disease,and participate in the pathophysiologic process of atherosclerosis directly or indirectly. To study these adipocytokines thoroughly would provide a new target for prevention and treatment of coronary heart disease.

关 键 词：脂肪细胞因子 动脉粥样硬化 冠心病 

分 类 号：R587.1[医药卫生—内分泌]