妊高征患者白细胞介素6变化的意义  

Clinical Significance of Changes of Interleukin 6 Level in Pregnancy Induced Hypertension

作　　者：王子芬[1] 宋海翔[1] 石少兰 张沂蒙[1] 王玉星[1] 

机构地区：[1]山东省临沂市中医医院妇产科

出　　处：《中华妇产科杂志》1999年第4期220-221,共2页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨妊高征患者白细胞介素６（ＩＬ６）变化的临床意义。方法用夹心酶联免疫法（ＥＬＩＳＡ）检测妊高征患者８２例（妊高征组）及正常妊娠妇女３０例（正常妊娠组）的血、尿中ＩＬ６的含量。结果重度妊高征患者血ＩＬ６含量较轻度妊高征患者和正常孕妇显著升高；妊高征组尿ＩＬ６含量均较正常妊娠组显著升高，且病情越重，升高越显著。妊高征组尿ＩＬ６与血肌酐（Ｓｃｒ）、内生肌酐清除率（Ｃｃｒ）分别成显著的正相关和显著的负相关关系，与尿β２微球蛋白（β２ＭＧ）、Ｎ乙酰βＤ葡萄糖苷酶（ＮＡＧ）分别成显著正相关。结论检测ＩＬ６有助于了解妊高征患者病情及其肾脏损害情况。Objective To assess the clinical significance of changes of interleukin 6 (IL 6) level in patients with pregnancy induced hypertension (PIH). Methods IL 6 level in urine and blood were measured by sandwich enzyme labeled immunosorbent assay (ELISA) in 82 patients with PIH and 30 normal pregnant women. Results Blood IL 6 level in severe PIH patients was signficantly higher than that in mild PIH patients and normal pregnant women. IL 6 level of urine in PIH patients were significantly higher than that in normal pregnant women and was associated with the severity of disease. There was a positive correlation between urinary IL 6 level and severity of renal damage in PIH. Conclusion Determination of IL 6 level is useful to understand the severity of PIH and its renal damage.

关 键 词：妊娠高血压 白细胞介素6 ELISA 肾脏损害 

分 类 号：R714.246[医药卫生—妇产科学]