糖皮质激素治疗气管支气管结核的对照研究  

Contrast study on glucocorticoid in treatment for tracheobronchial tuberculosis

作　　者：张耀亭[1] 杨松[1] 殷建团[1] 谢婷[1] 刘佳鑫[1] 肖雄[1] 

机构地区：[1]解放军第一七五医院南京军区结核病中心,福建漳州363000

出　　处：《临床肺科杂志》2010年第11期1558-1559,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨糖皮质激素(GC)对浸润型及坏死型气管支气管结核的治疗价值。方法 1997年1月至2009年2月住院的浸润型及坏死型气管支气管结核84例,随机分为治疗组(用GC组)和对照组(不用GC组)各42例,治疗组在全身抗结核治疗基础上加用强的松口服6周,对照组常规全身抗结核治疗。观察比较两组的疗效及转归。结果治疗组的有效率97.2%,显著高于对照组81.0%(P<0.05)。治疗后18个月纤支镜复查,治疗组结核性气管支气管狭窄发生率7.14%,显著低于对照组31.0%(P<0.01)。结论对炎症浸润型及溃疡坏死型气管支气管结核,早期适量应用糖皮质激素可提高疗效改善预后,减少气管支气管狭窄的发生。Objective To explore the effets of glucocorticoid（GC）in the treatment for tracheobronchial tubereulosis.Methods Eighty four cases with tracheobronchial tuberculosis were randomly divided into a GC group and a non-GC groups during January 1997 to February 2009.The GC group were treated by prednisone for 6 weaks based on general chemotherapy.The clinical effects and change were observed and compared between the two groups.Results The clinical efficacy rate of GC group （97.2%）was higher than the non-Gc group（81.0%）（P0.05）.The trachebronchial stenosis rate of GC group （7.14%） was lower than non-GC group（31.0%）（P0.01）.Conclusion The efficacy of GC in addition to chemotherapy is better than only chemotherapy in treatment of tracheobronchial tuberculosis ,can improve the prognosis and decrease the tracheobronchial stenosis rate.

关 键 词：糖皮质激素 气管支气管结核 药物治疗 

分 类 号：R521.2[医药卫生—内科学]