模型动物脾经穴位给药的药效研究  

Pharmacodynamic study of Drug Injection at Acupoints of Spleen Meridian in Model Animals

作　　者：林静瑜[1] 倪峰[1] 周春权[1] 胡翔龙[1] 许云禄[2] 

机构地区：[1]福建省中医药研究院,福建福州350003 [2]福建医科大学药学院,福建福州350004

出　　处：《福建中医学院学报》2010年第5期15-18,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省科技计划项目(99-Z-13);福建省卫生厅中医药科研计划项目(2002-401)

摘　　要：目的研究病理模型动物脾经穴位给药对"脾主统血"、"脾主运化"功能的影响。方法建立华法林钠病理出血家兔模型,在模型家兔脾经的穴位与非穴位点注射维生素K1,考察动物凝血酶原时间(PT)、白陶土部分凝血活酶时间(APTT)的变化;在盐酸消旋山莨菪碱胃肠动力障碍模型小鼠的脾经穴位与非穴点注射甲硫酸新斯的明,考察对模型动物胃排空、肠推进率的影响。结果 2种模型动物脾经穴位给药均能纠正其病理偏态,作用优于肌肉注射给药,脾经不同位点给药作用大小不同。结论经络穴位给药具有一定的药效特异性。Objective To investigate the effect of drug injection at acupoints of spleen meridian on splenic function, such as spleen being responsible for keeping blood within the vessels and spleen promoting transportation and transformation. Methods The rabbit model of pathological hemorrhage was established by the use of warfarin sodium, and the changes of prothrombin time （PT） and activated partial thrombeplastin time （AFTT were observed after Vitkl was injected into acupoint and non piont of spleen meridian. The rat model of gastrointestinal motility disorder was established by the use of racanisodamine hydrochloride, and the changes of gastric emptying and alvine pushing rate after eustigmin methylsulfate was injected into aeupeint and non piont of spleen meridian. Results The pathological skewness of two animal models could be retrieved by drug injection at acupoints of spleen meridian, the effect was superior to that of intramuscular injection, and drug injection at different point had different effect. Conclusion Drug administration via meridian points has a certain specificity of drug action.

关 键 词：穴位注射 脾经 药效特异性 出血模型 胃肠动力障碍模型 

分 类 号：R245[医药卫生—针灸推拿学]