我院2009年药物不良反应报告分析  

Analysis of Adverse Drug Reactions Reported in Our Hospital in 2009

作　　者：赵庚昊[1] 史强[1] 王荣乐[1] 

机构地区：[1]首都医科大学附属北京儿童医院,北京100045

出　　处：《儿科药学杂志》2010年第5期41-43,共3页Journal of Pediatric Pharmacy

摘　　要：目的:了解儿童药品不良反应发生的基本情况及其发生特点。方法:对我院2009年上报到国家药品不良反应监测网的251例ADR报表各项数据进行回顾性统计分析。结果:发生ADR的男性160例(63.75%),女性91例(36.25%),3岁以内幼儿发生ADR的比率为55.38%,为各年龄组中最高;引起ADR涉及到的药物中单一用药221例(88.05%),合并用药30例(11.95%),共涉及60种药物;涉及到抗感染药物的共157例,占总数的62.55%;ADR以皮肤损害为主;静脉滴注引起的ADR最高。结论:儿童药物不良反应发生有其特殊性,应加强儿童药物不良反应的监测并及时上报,以减少其发生率,减少后遗症,降低病死率。Objective：To find out characteristics of adverse drug reactions in children. Methods：Two hundred and fifty-one ADR cases reported to the National Adverse Drug Reaction Monitoring Network in 2009 were retrospectively analyzed. Results：There were 160 male cases （63.75%） and 91 female cases （36.25%）. The ADR rate of children below 3 years old was 55.38%,which was the highest among different age groups. Two hundred and twenty-one cases （88.05%） just used single drug and 30 cases（11.95%） used at least two drugs. ADR cases involved 60 kinds of drugs and 157 cases （62.55%） is related to anti-infective drugs. Skin damage was the main manifestation and intravenous drop infusion was the main administration method. Conclusions：The pediatric adverse drug reaction has some features. The monitoring of ADR of children should be strengthened,in order to reduce its incidence and decrease the morbidity and mortality.

关 键 词：儿童 药物不良反应 抗感染药物 

分 类 号：R965.3[医药卫生—药理学]