柞蚕蛹虫草多糖对乙硫氨酸致动物急性脂肪肝模型的影响  

Studies on the effect of CMPS on acute fatty liver induced by DL-E

作　　者：黄晓巍[1] 卢彤宇[2] 张永和[1] 

机构地区：[1]长春中医药大学附属医院实验研究中心,长春130021 [2]吉林省人民医院药剂科

出　　处：《国际中医中药杂志》2010年第5期394-395,共2页International Journal of Traditional Chinese Medicine

摘　　要：目的 观察柞蚕蛹虫草多糖（CMPS）对乙硫氨酸（DL-E）致动物急性脂肪肝模型的影响.方法 采用DL-E 250 mg/kg口服给药,制作动物急性脂肪肝模型,通过检测肝脏指数及甘油三酯（TG）含量及肝脏组织形态学变化,观察CMPS对动物模型肝脂肪蓄积的影响.结果 模型组动物肝肌指数和肝组织TG含量增加,光镜下肝小叶中央静脉周边可见肝细胞脂肪变性,肝细胞胞浆内出现大小不等的空泡样改变.CMPS给药组与模型组比较有明显改善.结论 DL-E可损伤动物肝脏并伴有肝脂肪蓄积;CMPS对肝损伤有保护作用.Objective To study the effect of CMPS on acute fatty liver induced by DL-E. Methods Oral administration DL-E （250 mg/kg） was given to mice to establish the models of acute fatty liver mice. Liver index, the contents of TG and morphological changes of liver tissue were detected to study the effect of CMPS on liver fat accumulation.Results The Liver index and the contents of TG in the model group rose. Under light microscope, lobular central vein could be seen around the liver steatosis and cytoplasm of liver cells appeared vacuolated changes. As compared with the model group, indexes significantly improved in CMPS group. Conclusion DL-E could obviously damage the liver and lead to liver fat accumulation. CMPS has protective effect on liver injury.

关 键 词：柞蚕蛹虫草多糖 乙硫氨酸 急性脂肪肝 

分 类 号：R285.5[医药卫生—中药学]