我国叶酸在妊娠中的应用有关文献分析  

Current situation of the studies on the using of Folic Acid in pregnant in China.

作　　者：谭春英[1] 

机构地区：[1]北京市海淀区妇幼保健院产前筛查中心,北京100080

出　　处：《中国优生与遗传杂志》2010年第10期58-59,6,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的了解我国有关叶酸在妊娠中的应用现状,明确进一步的研究方向。方法对CNKI中国期刊全文数据库进行全部检索,选择中国中文期刊有关"叶酸与妊娠"的论著类文献,按照纳入和排除标准进行文献选择,选中的文献由专人逐篇阅读,同时进行数据录入和分析。结果共检索到符合要求的文献189篇,其中基础类文献33篇(17.46%),临床类文献156篇(82.54%),这些文献中,叶酸与妊娠期高血压疾病的关系18篇(9.52%),叶酸与妊娠期贫血22篇(11.64%),叶酸与自发性流产15篇(7.94%),叶酸与出生缺陷19篇(10.05%),妊娠期叶酸水平的研究25篇(13.23%),叶酸与异位妊娠80篇(42.33%),其他(不能归入上述分类)10篇(5.29%)。全部文献中多中心的研究报告仅有2篇。结论在过去的近15年间,叶酸在妊娠中的作用不断受到人们的关注,但是简单的临床报道过多,创新性研究少,前瞻性、多中心、大规模临床研究欠缺。Objective：To understand the current situation of the studies of using Folic Acid（FA） in pregnant in China and to find the direction of futrue studies.Methods：In the CNKI Chinese full-text literature we found the sudies about the using of FA in pregnant according to the inclusion criteria.Those articles were reviewde by a specialized person and data were collected and analyzed.Results：Totally 189 articles were included in this study.In all articles,33 were of basic study（17.46%） and 156 were of clinical study（82.54%）.In all articles,the relation between FA and gestational hypertension（18,9.52%）,FA and animia（22,11.64%）,FA and spontaneous abortion（15,7.94%）,FA and birth defect（19,10.05%）,the degree of FA in pregnant（25,13.23%）,FA and ectopic pregnacy（80,42.33%） and others（10,5.29%）.Two papers in all were multi-centered reseach report.Conclusion：In the past 15 years,the study about FA draw remarkable attention in China,however,the clinical outcome reports are more and less creativity,and prospective multi-centered and large scaled clinical trial.

关 键 词：妊娠 叶酸 文献 中文 

分 类 号：R715[医药卫生—妇产科学]