我院2006～2008年抗菌药物应用与细菌耐药性分析  

Analysis of the Utilization of Antibiotics and Bacterial Resistance in Our Hospital from 2006 to 2008

作　　者：邓丽菁[1] 毕津莲[1] 李湘斌[1] 

机构地区：[1]南华大学附属第一医院药剂科,衡阳市421001

出　　处：《中国药房》2010年第38期3572-3575,共4页China Pharmacy

摘　　要：目的:了解我院抗菌药物的应用情况及细菌分离和耐药率的变迁特点。方法:调取我院2006～2008年抗菌药物的出库数据,采用限定日剂量法分析抗菌药物的应用情况,同时采用API半自动微生物鉴定系统及药敏卡进行病原菌鉴定及药敏试验。结果:3年中,第1、2代头孢菌素和其它β-内酰胺类抗生素的消耗数量逐年增加,而第3代头孢菌素和含β-内酰胺酶抑制剂复方制剂的应用率逐年降低;同期临床分离的细菌以革兰阴性杆菌为主(占76.2%～78.8%),大肠埃希菌对第3代头孢菌素和含β-内酰胺酶抑制剂复方制剂的耐药率有下降趋势。结论:我院临床分离的革兰阴性杆菌对常用抗菌药物的耐药现象较严重,限制广谱抗菌药物的应用可能减缓细菌耐药趋势。OBJECTIVE：To investigate the utilization of antibiotics,isolation of bacteria and the change characteristics of bacterial resistance rate in our hospital from 2006 to 2008.METHODS：The data about consumption of the antibiotics were collected from pharmacy department,and the utilization of antibiotics was analyzed using DDD analysis.The API half-automatic microbiological system and Vitek2 GNS seriation cards were used to identify the clinical isolated pathogenic bacteria and conduct drug susceptibility tests.RESULTS：The consumption of the first and second generation of cephalosporins and other β-lactam antiboitcs increased year by year while the utilization ratio of the third generation of cephalosporins and compound preparations containing β-lactamase inhibitor decreased over the three years.Gram-negative bacilli were predominant among the clinical isolated pathogenic bacteria（76.2%～78.8%）.The drug resistance rate of Escherichia coli against third generation of cephalosporins and compound preparations containing β-lactamase inhibitor showed the declining tendency from 2006 to 2008.CONCLUSION：Clinical isolated gram-negative bacilli shows severe drug resistance to general antibiotics in our hospital.The restriction on the utilization of broad spectrum antibiotics contributes to deceasing bacterial resistant.

关 键 词：抗菌药物 用药频度 细菌耐药 

分 类 号：R969.3[医药卫生—药理学] R287[医药卫生—药学]