帕瑞昔布抑制老年患者瑞芬太尼全麻术后急性疼痛的效果观察  

Clinical Efficacy of Parecoxib for Acute Postoperative Pain after Remifentanil-induced Anesthesia in Elderly Patients

作　　者：陈栋樑[1] 陈雷[1] 叶青山[1] 楼静芝[1] 

机构地区：[1]浙江绍兴市人民医院,绍兴市312000

出　　处：《中国药房》2010年第38期3606-3608,共3页China Pharmacy

摘　　要：目的:观察帕瑞昔布抑制老年患者瑞芬太尼全麻术后急性疼痛的效果。方法:60例美国麻醉师协会(ASA)Ⅰ～Ⅱ级老年瑞芬太尼全麻患者随机分为3组,分别于术毕前1h静注帕瑞昔布40mg(Ⅰ组)、曲马多100mg(Ⅱ组)、氯诺昔康8mg(Ⅲ组)。比较3组术后平均动脉压(MAP)、心率(HR)、疼痛视觉模拟评分法(VAS)评分及并发症。结果:Ⅲ组的MAP、HR明显升高(P<0.05);Ⅲ组的VAS评分及烦躁高于Ⅰ、Ⅱ组(P<0.05);Ⅱ组的呕吐发生率最高(P<0.05)。结论:帕瑞昔布镇痛效果与曲马多相似,强于氯诺昔康,能有效抑制老年患者瑞芬太尼全麻术后急性疼痛,且不良反应少。OBJECTIVE：To observe the effect of parecoxib on acute postoperative pain after remifentanil-induced anesthesia in elderly patients.METHODS：60 elderly patients with remifentanil-induced anesthesia（ASA graded Ⅰ ～Ⅱ） were randomized into 3 groups.1 hour before the end of operation,group Ⅰ were given 40 mg parecoxib and group Ⅱ 100 mg tramadol,group Ⅲ 8 mg lornoxicam.The MAP,HR and VAS scoring of 3 groups were compared at the end of operation.RESULTS：The level of MAP and HR of group Ⅲ were increased significantly（P0.05）;The VAS scoring and incidence of dysthesia in group Ⅲ were both higher than in group Ⅰ and group Ⅱ（P0.05）.The incidence of vomiting in group Ⅱ was the highest（P0.05）.CONCLUSION：Parecoxib has effect on acute postoperative pain after remifentanil-induced anesthesia,which is the same to tramadol and better than lornoxicam.

关 键 词：帕瑞昔布 瑞芬太尼 老年 术后疼痛 

分 类 号：R971.2[医药卫生—药品] R969.4[医药卫生—药学]