米非司酮用于足月妊娠引产后的胎盘病理学改变  

The Placental Pathologic Changes in Induced Labor of Full-term Pregnancy by Mifepristone

作　　者：徐箴[1] 陆惠娟[1] 姜学智[1] 张振钧[1] 杜明昆[1] 

机构地区：[1]上海医科大学妇产科医院

出　　处：《中国实用妇科与产科杂志》1999年第5期299-300,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的观察米非司酮用于足月妊娠引产后的胎盘病理改变。方法将２０例引产指征为预防妊娠过期的孕妇随机分为２组，治疗组１０例予米非司酮５０ｍｇ每日２次口服，连服２天，第３天予米索２５μｇ每６小时阴道塞置；对照组予蒂落安２００ｍｇ每日１次静脉推注，连用３天，第４天人工破膜后，静脉滴注催产素２５ＩＵ加５％葡萄糖５００ｍｌ，每分钟８滴始。两组均于分娩后取胎盘及蜕膜标本在光镜及电镜下观察。结果与对照组相比，治疗组胎盘及蜕膜未发生显著改变，且明显轻于米非司酮用于中孕引产时。结论根据胎盘病理学研究显示，米非司酮用于足月引产是安全可靠的。Objective\ To investigate the placental pathologic changes in induced labor of full-term pregnancy.Methods\ 20 full-term pregnancy women,with indication of induced labor for preventing prolonged pregnancy,were assigned to 2 groups randomly.10 cases in the test group were treated with mifepristone 50mg,Bid,po,for the first 2 days,and misoprostol 25μg,q6h,pv,in the third day.The other 10 cases in the control group were treated with prastronum sulfas 200mg,Qd,iv,for 3 days,then synthsized inductioninon the fourth day.The placenta and decidua of the two groups were observed by light and electron microscopy.Results\ No significant changes were observed in the placenta and decidua in test group compared with the control group,and changes were less than those in second tri-term pregnancy labor induction by mifepristone.Conclusions\ Mifepristone was safe in labor induction according to placental pathological study.

关 键 词：米非司酮 足月妊娠 胎盘 病理学 药物引产 

分 类 号：R719.31[医药卫生—妇产科学] R714.56[医药卫生—临床医学]