补骨脂盐炙前后对正常小鼠和氢化可的松致阴虚模型小鼠燥毒的影响  

Dry Toxic Effects of Fruit of Psoralea Corylifolia L.Processed with Salt on Normal Mice and Yin Deficiency Mice Induced by Hydrocortisone

作　　者：胡昌江[1] 帅小翠[1] 余凌英[1] 徐志毅[1] 张然[1] 王智鹏[1] 

机构地区：[1]成都中医药大学药学院,四川成都611137

出　　处：《成都中医药大学学报》2010年第3期66-68,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家十一五科技支撑计划(编号:2006BAI09B0609)

摘　　要：目的:观察补骨脂盐炙前后对正常小鼠和氢化可的松阴虚模型小鼠燥毒的影响。方法:用补骨脂生品、水炙品、盐炙品醇水双提液灌胃给药,记录每天饮水量和饮食量,7天后测定小鼠血浆cAMP、cGMP,并计算其比值,同时称取其胸腺,脾,睾丸的重量,计算器官系数(器官重/体重)。结果:对正常小鼠:补骨脂盐炙品cAMP/cGMP值低于补骨脂生品和水炙品,胸腺系数、脾系数高于生品和水炙品,饮食量低于生品和水炙品,睾丸系数和水量三者差异不大;对模型小鼠:补骨脂盐炙品cAMP/cGMP值低于补骨脂生品和水炙品,胸腺系数高于生品和水炙品,脾系数、睾丸系数、食量、水量三者差异不大。结论:补骨脂经盐炙后可以缓和生品的燥毒之性。Objective：To observe The dry toxic effects of the fruit of Psoralea corylifolia L.which is processed with salt or not on normal mice and yin deficiency mice induced by hydrocortisone,Methods：Food mice wtih the alcohol-water extractive of the fruit of Psoralea corylifolia L.for 7 days,record the amount of daily water intake and diet,after 7days,measure the cAMP,cGMP of the blood plasma,calculate cAMP/cGMP,anatomise the mouse,and take away the thymus,the spleen,the testicle and weigh it,calculate coefficient of the organs.Results：The normal mice： the salt-product,cAMP /cGMP is lower than the not processed product and water-product,thymus factor,spleen coefficient is higher than the not processed product and water-product,and food intake is lower than the not processed product and water-product,the difference of testicular factors and water intake between the three is unconspicuous;the hydrocortisone mice： the salt-product,cAMP /cGMP is lower than the not processed product and water-product,thymus factor is higher than the not processed product and water-product,spleen factor,testis factor,food intake,water intake show little difference.Conclusion：the salt-fruit of Psoralea corylifolia L.can ease the dry poison of which is not processed.

关 键 词：补骨脂 盐炙 CAMP/CGMP 器官系数 燥毒 

分 类 号：R283.1[医药卫生—中药学] R285.5[医药卫生—中医学]