体外受精失败的原因及对策  

IVF failure and countermeasures

作　　者：刘平[1] 郑晓英[1] 

机构地区：[1]北京大学第三医院生殖医学中心,北京100191

出　　处：《中国实用妇科与产科杂志》2010年第10期758-761,共4页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：在接受体外受精胚胎移植治疗的患者中,有时会出现全部获取的卵母细胞均未受精现象,即受精失败。其原因可能为精子与透明带结合失败和(或)精子穿透异常、卵母细胞激活失败等。目前尚缺乏准确的预测受精失败的方法,临床上一旦出现受精失败应采取积极的补救措施,并根据患者病史、临床特征、配子情况对患者以后的治疗措施提出建议。早补救ICSI的有效性和安全性尚需进一步的临床验证。Total fertilization failures （TFF） are rare events of in vitro fertilization （IVF）. Most cases occur due to lack or dysfunction of sperm binding to/ penetrate the zona pellucida or failure of oocyte activation. Fertilization failure is not predictable because of lacking accurately and sensitive method. The clinical value of rescue ICSI should be fully considerable according to patient history, clinical character and gametes quality. Long term evaluation of babies resulting from the application of early rescue ICSI is needed to confirm empirically the safety of this method.

关 键 词：受精 完全受精失败 补救卵母细胞浆内单精子注射 卵母细胞激活 

分 类 号：R71[医药卫生—妇产科学]