复方萘替芬喷雾剂及冷霜的研制与应用  

Preparation and application of compound naftifine vapour and cream

作　　者：廖万清[1,2] 李志刚[1,2] 温海[1,2] 吴建华[1,2] 葛绳德[1,2] 

机构地区：[1]第二军医大学长征医院皮肤科 [2]第二军医大学长海医院烧伤科

出　　处：《第二军医大学学报》1999年第3期187-188,共2页Academic Journal of Second Military Medical University

基　　金：军队"九五"医学科研规划重点资助

摘　　要：目的：观察烧伤创面抗真菌感染及防治浅部真菌病外用新药复方萘替芬（Ｓ１１２３）的体外抑菌效果和临床疗效。方法：（１）体外检测萘替芬、酮康唑和Ｓ１１２３的最低抑菌浓度，比较３种药物的抗真菌效果；（２）将Ｓ１１２３和对照药品应用于烧伤创面，在治疗前后取创面痂皮进行真菌培养，观察真菌转阴率；（３）观察Ｓ１１２３冷霜治疗某舰艇部队浅部真菌病患者１９２７例的效果。结果：Ｓ１１２３对丝状真菌和酵母菌具有广谱、高效的抑菌作用，对常见的致病真菌——曲霉和念珠菌，其最小抑菌浓度分别为０．１５６，０．６２５μｇ／ｍｌ。临床使用双盲法观察３ｄ真菌感染转阴率达７７．７１％，与对照组比较相差非常显著。对浅部真菌病治疗的有效率为９５．６％。结论：Ｓ１１２３是一种疗效很好的外用抗真菌新药。To evaluate the effects of a new antifungal agent, S1123, on controlling fungal infection on burn wound in vitro and in clinic. Methods: Compare their antifungal effects with 3 different antifungal drugs, naftifine, ketoconole and S1123 by testing their minimal inhibitory concentration (MIC). S1123 and a control drug were used to treat burn wound. The crusts were taken to culture before and after treatment for calculating the negative rate. One thousand nine hundred and twenty seven patients suffered superficial mycoses on naval vessels were treated with S1123 cream. Results: S1123 was active in vitro against a broad spectrum of fungal and yeast pathogens. MIC of Aspergillus and Candida , 2 main pathogenic genura, was 0.156,0.625 μg/ml. In the clinical administration, invasive fungi of 79 71% burn wound disappeared in 3 d. Compared with the controls, the difference being signifficant statistically ( P <0.01). The effective rate on superficial mycoses was 95.6%. Conclusion: S1123 is an new effective external antifungal drug.

关 键 词：烧伤 真菌病 萘替芬 药物疗法 喷雾剂 冷霜 

分 类 号：R644.05[医药卫生—外科学] R978.5[医药卫生—临床医学]