妊娠早期人体胎盘中单胺氧化酶活性的测定  

DETERMINATION OF MAOA ACTIVITY IN HUMAN PLACENTA AT EARLY STAGE

作　　者：徐宏伟[1,2,3] 杜卫[1,2,3] 王秀丽 张爱青[1,2,3] 张崇理 

机构地区：[1]青岛医学院生物化学教研室 [2]青岛医学院附属医院妇产科 [3]中科院动物所计划生育生殖生物学国家重点实验室

出　　处：《青岛医学院学报》1999年第1期41-42,共2页Acta Academiae Medicinae Qingdao Universitatis

基　　金：中科院动物所计划生育生殖生物学国家重点实验室课题

摘　　要：目的探讨妊娠早期人体胎盘中单胺氧化酶（ＭＡＯ－Ａ）活性与早期妊娠的关系。②方法应用分光光度法检测了妊娠５～９周人体胎盘绒毛中ＭＡＯ－Ａ活性。③结果随妊娠周数的增加，ＭＡＯ－Ａ活性增加。第８，９周胎盘绒毛中ＭＡＯ－Ａ活性明显高于第５周（Ｆ＝５．４４，ｑ＝３．７３，５．５４，Ｐ＜０．０５，０．０１）和第６周（ｑ＝３．０７，４．８３，Ｐ＜０．０５，０．０１）。其他各组间比较，差异无显著性（ｑ＝０．１０～２．６９，Ｐ＞０．０５）。④结论妊娠早期人体胎盘绒毛中ＭＡＯ－Ａ活性的变化，可能与妊娠过程神经递质或激素的合成和释放有关。\ Objective \ To study the activity of MAOA in human placenta at early pregnant stage and its relationship with pregnancy.\ X]Methods \ Spectrophotometric method was performed to estimate the activity of MAOA in villous chorion of human placenta during 5th-9th pregnant weeks.\ Results \ The activity of MAOA increased along with the pregnant period. The activity of MAOA between 8th and 9th week was significantly higher than that of 5th week(F=5.44, q=3.73, 5.54, P<0.01) and 6th week(q=3.07, 4.83, P<0.05, 0.01).\ Conclusion \ MAOA existed in the villous chorion of human placenta. The changes of its activity was related to the biosynthesis and release of neurotransmitters or hormones during pregnancy.\;

关 键 词：单胺氧化酶 胎盘 活性 分光光度法 

分 类 号：R714.560.4[医药卫生—妇产科学]