米多君、硝酸甘油贴膜治疗老年体位性低血压合并卧位高血压疗效观察  

Midodrine plus Nitroderm TTS on Patients with Orthostatic Hypotension and Supine Hypertension: A Clinical Study

作　　者：黄志刚[1] 乔延国[2] 田野[3] 

机构地区：[1]解放军第305医院,北京100017 [2]武警总医院,北京100039 [3]哈尔滨医科大学附属第二医院,哈尔滨150086

出　　处：《中国医院用药评价与分析》2010年第9期832-834,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察米多君、硝酸甘油贴膜联合治疗老年性体位性低血压(OH)合并卧位高血压(SP)的疗效。方法:随机分组进行试验观察,对照组22例,给予综合性基础治疗。治疗组21例,在综合性治疗的基础上日间给与米多君口服,夜间给与硝酸甘油贴膜贴敷,治疗老年性日间高血压合并夜间卧位性高血压。观察治疗第30d的动态血压和低血压致大脑低灌注发生情况。结果:治疗组日间平均收缩压(108.22±14.62)mmHg,较对照组的(89.15±12.17)mmHg明显增高(P﹤0.05)。日间因为体位性低血压导致大脑低灌注如跌倒、晕厥等症状发生率较对照组明显减少(P﹤0.01);治疗组夜间平均收缩压为(133.70±14.21)mmHg,较对照组的(154.71±17.52)mmHg明显减低(P﹤0.01)。结论:在综合性治疗的基础上联合应用米多君、硝酸甘油贴膜治疗体位性低血压合并卧位高血压疗效可靠,可同时有效控制日间低血压与夜间高血压。OBJECTIVE ： To observe the effects of midodrine plus nitroderm TTS on elderly orthostatic hypotension complicating supine hypertension. METHODS： A total of 43 patients with elderly orthostatic hypotension complicating supine hypertension were randomly assigned to either control group（n = 22） treated with comprehensive therapy alone or treatment group（n = 22） receiving comprehensive therapy in combination with oral midodrine during daytime plus nitroderm TTS in the nighttime. On day 30, the occurrence of cerebral hypoperfusion induced by ambulatory blood pressure （ABP） and hypotension were observed. RESULTS： The mean systolic pressure during daytime was significantly higher in the treatment group than in the control group [ （ 108.22 ±14.62） mmHg versus （89.15 ± 12. 17） mmHg, P 〈 0.05 ] ; the incidence of syncope or cataplexy due to cerebral hypoperfusion in day time was significantly less than in the control group（P 〈 0.01 ）; The mean systolic pressure during nighttime was significantly lower in the treatment group than in control group [ （133.70 ± 14.21 ） mmHg vs. （154.71 ±17.52） mmHg, P 〈 0.05 ]. CONCLUSION ： Midodrine plus nitroderm TTS in combination with comprehensive therapy is safe and effective in the treatment of elderly patients with orthostatic hypotension complicating supine hypertension, and by which, patients＇ daytime hypotension and nighttime hypertension are all under effective control. KEY WORDS Orthostatic hypotension; Supine hypertension; Treatment

关 键 词：体位性低血压 卧位高血压 治疗 

分 类 号：R972[医药卫生—药品]