中、老龄男性血清睾酮和皮质醇含量变化规律的研究  

Studies on the changes of serum levels of testosterone and cortisol in heathy middle, older men

作　　者：郭丛慧[1] 刘喜春[1] 李洪岩[1] 王岩[1] 刘睿智[1] 陈善明 全邦兴 张羽 

机构地区：[1]白求恩医科大学生殖病理生理研究室

出　　处：《中国病理生理杂志》1999年第5期470-472,共3页Chinese Journal of Pathophysiology

摘　　要：目的：研究中老年男性血清睾酮和皮质醇含量变化及规律。方法：５８１例４０岁以上健康男性以每１０年为一年龄组，分为４组。以２０～３９岁健康男性１１０例作为对照组。均于上午８～１０时静脉采血，分离血清，应用放免分析方法检测血清睾酮和皮质醇含量。结果：（１）４０岁以上各组血清睾酮含量与年轻组比较明显下降（Ｐ＜００１），血清皮质醇含量逐渐增加，与对照组比较均差异显著（Ｐ＜００１）；（２）血清睾酮与皮质醇含量呈显著负相关（ｒ＝－０．３０９６，Ｐ＜００１）。结论：随增龄睾丸的内分泌功能逐渐下降。AIM: To study the change of serum levels of testosterone (T) and cortisol (CORT) in heathy middle, older men .METHODS:Serum levels of T and CORT was measured by RIA in 581 healthy men (age 40～89) which were divided into four groups according to their age and 110 healthy men (age 20～39) as control group.RESULTS:(1) Serum T levels was significently decreased ( r=-0.5144, P<0.01 ) in groups over 40 years old compared with the controls, while serum CORT levels was increased ( r=0.2809, P<0.01 ) compared with the controls; (2) Serum levles of T and CORT was in a negative correlation ( r=-0.3096, P<0.01 ).CONCLUSION:Testicular endocrinological function was gradually declined with age, while adrenocortical function was increased.

关 键 词：睾酮 氢化可的松 衰老 血清 

分 类 号：R339.38[医药卫生—人体生理学] R362[医药卫生—基础医学]