白细胞介素8与心肌酶水平在小儿支气管肺炎诊治中的临床意义  

Clinical significance of sermn interleukin-8 and myocardial enzyme levels in the diagnosis and treatment of children with bronchopneumonia

作　　者：张建梅[1] 陈欣[1] 任静[1] 郝锦丽[1] 张亚京[1] 

机构地区：[1]内蒙古医学院第三附属医院儿科,包头014010

出　　处：《中国医师进修杂志》2010年第28期15-17,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨白细胞介素8（IL-8）及心肌酶水平与小儿支气管肺炎的关系.方法 采用放射免疫法对60例支气管肺炎患儿（分为轻型肺炎组30例及重型肺炎组30例）进行了IL-8水平检测,采用日本产Olympus AU640全自动生化分析仪检测心肌酶,并与30例健康体检儿童（对照组）比较.结果 重型肺炎组、轻型肺炎组患儿血清IL8水平分别为（2.54±0.65）、（1.28±0.53）μg/L,与对照组的（0.43±0.08）μg/L比较差异有统计学意义（P＜0.01）,重型肺炎组、轻型肺炎组血清心肌酶水平（α-羟丁酸脱氢酶、肌酸激酶同工酶-MB、肌酸激酶、天冬氩酸氨基转移酶、乳酸脱氢酶）与对照组比较差异有统计学意义（P＜0.01）.结论 IL-8、心肌酶参与了小儿支气管肺炎的发病,检测支气管肺炎患儿血清IL-8和心肌酶水平变化对诊断、治疗和预后均有一定的临床意义.Objective To investigate the association of serum interleukin-8 （IL-8） and myocardial enzyme levels in children with bronchopneumonia.Methods Serum IL-8 contents were measured by the radioimmunity method and serum myocardial enzyme contents were measured by the Olympus AU640 in 60 children with bronchopneumonia （mild 30 cases and severe 30 cases） as well as in 30 controls.Results Serum IL-8 contents were significantly higher in children with severe bronchopneumonia and mild bronchopneumonia than those in controls [（ 2.54 ± 0.65）,（ 1.28 ± 0.53） μ g/L vs.（0.43 ± 0.08） μ g/L] （P 〈0.01）,and serum myocardial enzyme contents （α-hydroxybutyrate dehydrogenase,MB isoenzyme of creatine kinase,creatine kinase,aspartate aminotransferase） were significantly higher in children with severe bronchopneumonia and mild bronchopneumonia than those in controls （P〈0.01）.Conclusions IL-8 and myocardial enzyme may play a role in children with bronchopneumonia.Determination of serum IL-8 and myocardial enzyme levels might have important prognostic values in children with bronchopneumonia.

关 键 词：支气管肺炎 白细胞介素8 心肌酶 

分 类 号：R72[医药卫生—儿科]