2,2'-双氧代-4,4'-二苯基-5,5'-三亚甲基-6,6'-螺-双六氢嘧啶的绿色合成  

Green Synthesis of 2,2'-dioxo-4,4'-diphenyl-5,5'-trimethylene-6,6'-spirobishexahydropyrimidine

作　　者：米成根[1] 贺楚华[1] 谢成[1] 开永茂[1] 张卿菘[1] 

机构地区：[1]南华大学化学化工学院,湖南衡阳421001

出　　处：《化工时刊》2010年第9期14-16,19,共4页Chemical Industry Times

基　　金：湘教通[2008]269号第一批湖南省大学生研究性学习和创新性试验计划项目(序号121)

摘　　要：以聚乙二醇-400为溶剂,以环己酮、苯甲醛、尿素为原料一锅煮合成2,2'-双氧代-4,4'-二苯基-5,5'-三亚甲基-6,6'-螺-双六氢嘧啶,探索催化剂及溶剂的用量、反应物配比、反应时间、反应温度对反应的影响,得到最佳反应条件为:n(环己酮)∶n(苯甲醛)∶n(尿素)=1.0∶2.5∶3.0、10 mL聚乙二醇-400、0.54 g对甲苯磺酸,反应温度100℃,反应时间5.0 h,产品收率为82.1%。2,2＇-dioxo-4,4＇-diphenyl-5,5＇-trimethylene-6,6＇-spirobishexahydropyrimidine was synthesized using cyclohexanone,benzaldehyde and urea as materials in the polyethylene glycol-400.The effects of amount of catalyst and solvent,molar ratio of the reactant,the reaction time and the reaction temperature were investigated.The optimum reaction conditions were determined as follows：n（cyclohexanone）∶n（benzaldehyde）∶n（urea）=1.0∶2.5∶3.0,toluene sulfonic acid 0.54 g,10 mL polyethylene glycol-400,reaction time 5.0 h under the temperature 100℃,The yield of product was up to 82.1%.

关 键 词：2 2'-双氧代-4 4'-二苯基-5 5'-三亚甲基-6 6'-螺-双六氢嘧啶 聚乙二醇-400 绿色合成 

分 类 号：O621.3[理学—有机化学]