156例癫癎患者治疗药物浓度与不良反应监测  

Monitoring for Drug Concentration and Adverse Reaction in 156 Cases of Patients of Epilepsy

作　　者：王锦秋[1] 王民[2] 丰艳梅[1] 蔡艳[1] 张抗怀[1] 

机构地区：[1]西安交通大学医学院第二附属医院药剂科,710004 [2]西安交通大学药业集团,710061

出　　处：《医药导报》2010年第10期1384-1386,共3页Herald of Medicine

基　　金：陕西省科学技术研究发展计划项目[基金编号:2006k14-G5(3)]

摘　　要：目的分析抗癫癎药物治疗过程中不良反应与血药浓度间的关系,探讨其安全使用问题。方法对156例发现不良反应的病例进行治疗药物监测,并对结果进行评估分析。结果肝功能异常者53例,体质量增加者74例,记忆力降低、学习能力减退12例,精神萎靡、乏力、嗜睡者5例,全身大面积皮疹3例(均服用卡马西平),全身不自主抽搐1例,脱发2例,凝血障碍导致鼻出血3例,牙龈增生1例,中毒2例。结论癫癎患者治疗过程中有必要加强血药浓度与不良反应的监测,保证用药安全。Objective To analyze the relationship of adverse reaction and serum concentration of anti-epileptic drugs and to investigate the safety use of them. Methods Drug monitoring was carried out on 156 cases of patients had adverse drug reactions,and the results were assessed. Results 53 cases showed abnormal liver function after treatment;74 cases gained body weight;12 cases showed memory and learning ability decrease;5 cases in low spirits,debility and lethargy;3 cases had a large area skin rash all over the body;1 showed the whole body involuntary convulsion;2 alopecie;3 nose blood;1 case gingiva hyperphasia and 2 toxication. Conclusion During treatment for epilepsia,drug concentration monitoring should be accompanied with drug adverse reaction management to ensure the safety of patients.

关 键 词：抗癫癎药物 不良反应监测 药物监测 游离药物监测 

分 类 号：R971.6[医药卫生—药品]