青蒿素脂质体的制备及性能研究  

Preparation of Artemisinin Liposomes and Study on Its Performance

作　　者：瞿建江[1] 冯淑华[2] 

机构地区：[1]扬州大学医学院,江苏扬州225001 [2]北京联合大学生物化学工程学院,北京100023

出　　处：《北京联合大学学报》2010年第3期14-18,22,共6页Journal of Beijing Union University

摘　　要：目的:通过对青蒿素脂质体的处方和制备工艺研究,研制高包封率和稳定的脂质体。方法:采用乙醇注入法制备脂质体,以正交实验优化处方,测定了脂质体中药物的包封率,并初步考察了脂质体的稳定性。结果:优化处方与工艺所得脂质体形态均匀,包封率大于85%,载药量达27.22%,粒径约为90 nm,Zeta电位约为-68.4 mV,具有良好的稳定性。结论:乙醇注入法制备脂质体工艺简便,包封率高,制备的脂质体稳定好。Purpose： To obtain a stable artemisinin liposome with high trapping efficiency by selecting formulation and preparation of artemisinin liposome.Method： The artemisinin liposomes were prepared by film-ultrasound method.The formulation was optimized by orthogonal design.The trapping efficiency and the stability were determined.Result：The trapping efficiency of the artemisinin liposome reached 85%,the drug amounted to 27.22%,the particle size of the liposome was 90 nm and the zeta potential was-68.4 mV.The liposome has good stability.Conclusion：The method can be used to prepare a stable artemisinin liposome with high trapping efficiency.

关 键 词：青蒿素 脂质体 包封率 质量评价 

分 类 号：R978.61[医药卫生—药品]