甲磺酸帕珠沙星与维生素C的配伍稳定性考察  

Compatible Stability of Pazufloxacin Mesylate for Injection Mixing with Vitamin C Injection

作　　者：张婉婷[1] 杨艳[1] 

机构地区：[1]遵义医学院附属医院药剂科,贵州遵义563003

出　　处：《中国药业》2010年第19期13-14,共2页China Pharmaceuticals

摘　　要：目的考察甲磺酸帕珠沙星与维生素C注射液配伍的稳定性。方法采用紫外双波长分光光度法,分别测定甲磺酸帕珠沙星与维生素C注射液配伍前后溶液的含量变化,并观察配伍液的外观、pH。结果在室温(25℃)条件下,甲磺酸帕珠沙星与维生素C注射液配伍后0～6 h内溶液的含量、pH、外观等均有明显的变化。结论甲磺酸帕珠沙星与维生素C注射液不宜配伍使用。Objective To observe the compatibility of Pazufloxacin Mesylate for Injection with Vitamin C Injection.Methods UV double wavelength spectrophotometry was adopted to detect the content change before and after combination of Pazufloxacin Mesylate for Injection with Vitamin C Injection.The change of the combination solution in appearance and pH were observed at room temperature.Results Sig-nificant change was found in the content,color and pH value for the mixed solution determined at different time within 0-6 h after mixing at room temperature.Conclusion Pazufloxacin Mesylate for Injection can not be mixed with Vitamin C Injection for clinical use.

关 键 词：维生素C 甲磺酸帕珠沙星 紫外双波长分光光度法 配伍稳定性 

分 类 号：R969.2[医药卫生—药理学] R978.69[医药卫生—药学]