乳康平对“肝郁型”乳腺增生病模型的干预作用  

Effects of Rukangping on Cyclomastopathy Rats with Syndrome of Liver-QI Stagnation

作　　者：邓国兴[1] 王文智[1] 李春香[1] 丁芳[2] 王亮[2] 吴中秋[1] 

机构地区：[1]河北医科大学中医学院,石家庄050091 [2]河北医科大学第三医院,石家庄050051

出　　处：《中国中医基础医学杂志》2010年第9期777-779,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：河北省科技攻关计划(06276102D-34)

摘　　要：目的:研究乳康平对"肝郁型"乳腺增生病大鼠的干预作用。方法:通过连续、不定时的强迫游泳方法复制"肝郁型"乳腺增生模型,以逍遥丸作为对照分别灌服不同剂量的乳康平进行研究。实验过程中观察各组大鼠的一般状况,采用游标卡尺测量大鼠第2、3对乳头直径,采用化学试剂盒测定血清中生殖激素6项水平,采用HE染色光镜观察大鼠乳腺组织变化情况。结果:乳康平可以改善"肝郁型"乳腺增生病大鼠的一般状况,缩小乳腺增生病大鼠的乳头直径,调节生殖激素的平衡,减轻乳腺组织的病理变化。结果显示,乳康平中剂量组治疗"肝郁型"乳腺增生病大鼠的效果优于其他治疗组。结论:乳康平对"肝郁型"乳腺增生病大鼠有明显的治疗作用。Objective： To research the effect of Rukangping on cyclomastopathy rats with stagnation of liver-QI.Methods：Make the cyclomastopathy model of rats with stagnation of liver-QI by forcing swimming method from time to time continuously.Xiaoyao pill was selected as a control,the cyclomastopathy model of rats were fed with different doses of Rukangping.During the course of the experiment,the general state of all rats in each group were observed.The papilla diameter between the second and the third were measured by vernier caliper,and the six kind of reproduction hormones were determined,and the pathology changes in breast tissue were observed by optical microscope.Results： Rukangping could improve the general state of the cyclomastopathy rats with stagnation of liver-QI.Rukangping can reduce the papilla diameter of cyclomastopathy rats with stagnation of liver-QI,and regulate hormone balance,improve the pathological changes of breast tissue.Xiaoyao pill also had the same role,but the findings showed that effects of medium-dose Rukangping was better than that of other treatment group.Conclusion： Rukangping had obvious therapeutic effects on the cyclomastopathy rats with stagnation of liver-QI.

关 键 词：乳腺增生 肝郁 乳康平 大鼠 

分 类 号：R285.5[医药卫生—中药学]