血清胱抑素C在肾病诊断中的应用  

Cystatin C can diagnoze kidney diseases early

作　　者：陈波[1] 黄海樱[1] 陈曼铌[1] 周芸[1] 冯桂玲[1] 林敏[1] 

机构地区：[1]广州医学院第二附属医院,广东广州510260

出　　处：《海南医学》2010年第19期104-106,共3页Hainan Medical Journal

摘　　要：目的探讨血清胱抑素C(Cys-C)的检测在肾病诊断中的价值。方法应用微粒子增强比浊法检测各种肾病患者的血清胱抑素C浓度,同时采用Jaffe法测定血清肌酐(Scr),并计算内生肌酐清除率(Ccr),并进行相关的统计分析。结果 Cys-C的水平随肾功能的减退而逐渐升高,在Ccr≥80ml/min的患者中,Cys-C异常率为5%,Scr异常率为0;在20ml/min≤Ccr<80ml/min的患者中,Cys-C异常率为68%,Scr异常率为53%;在Ccr<20ml/min的患者中,Cys-C与Scr的异常率均为100%。结论血清胱抑素C(Cys-C)是反映肾功能损害的早期敏感标志物,为临床及时发现早期肾病并对其作出诊断提供了判断依据。Objective To explore value of the applicability of cystatin C in diagnosing early in kidney diseases.Methods Serum cystatin C concentration was determined by particle-enhanced turbidimetry,serum creatinine （Scr） by Jaffe method and Creatinine clearance rate were measured.Results The level of serum cystatin C was gradually elevating along with the decrease of endogenous creatinine clearance.Conclusion Serum cystatin C is a early sensitive marker to reflect the kidney function injure,and provide judgment basis for diagnosing kidney diseases early.

关 键 词：血清胱抑素C 血清肌酐 肌酐清除率 肾小球滤过率 

分 类 号：R446.11[医药卫生—诊断学]