青年人肾病综合征28例分析  

Clinical analysis on manifestations of nephritic syndrome in 28 young men

作　　者：李照辉[1] 徐丽娟[1] 卢晓昭[1] 罗会文[1] 邹晓荣[1] 

机构地区：[1]解放军第323医院,陕西西安710054

出　　处：《现代医药卫生》2010年第21期3231-3232,共2页Journal of Modern Medicine & Health

摘　　要：目的:分析青年人肾病综合征的临床和病理特点,以期提高诊治水平。方法:分析28例青年肾病综合征患者的临床、病理及治疗情况。结果:28例患者病理表现为IgA肾病的17例,非IgA系膜增生性肾炎的8例,局灶节段性肾小球硬化性肾炎1例,另2例未行肾活检。其中,28例均使用足量强的松+环磷酰胺冲击,辅于ACEI、潘生丁等综合治疗。3个月完全缓解率50%(14/28),部分缓解率35.7%(10/28),总缓解率85.7%(24/28)。6个月完全缓解率42.8%(12/28),部分缓解率39.2%(11/28),总缓解率82.1%(23/28)。半年复发率74.0%(20/27)。结论:青年人肾病综合征患者中IgA肾病居多,通过激素+环磷酰胺治疗后可有效缓解,但半年复发率高。Objective：To analyse the clinical and pathologic features of nephritic syndrome in 28 young men in order to increase the diagnostic level.Methods：A retrospective review of 28 cases of nephritic syndrome within 4 years（2003 to 2007）were conducted to summarize clinical manifestations,pathological features and therapeutic results.Results：There were 17 cases of immunoglobulin A nephropathy（IgAN）,8 cases of non-IgA mesangial proliferative glomerulonephritis,1 cases of focal segmental glomerulosclerosis（FSGS）by renal biopsy,2 cases without renal biopsy.The impact therapy prednisone combined CTX was given to all 28 cases.In the first 3 months,CR rate was 50%（14/28）,PR rate 35.7%（10/28）,and the overall response rate was 85.7%（24/28）.To the first 6 months,CR was 42.8% （12/28）,PR rate was 39.2%（11/28）.The overall response rate was 82.1%（23/28）.A half-year recurrent rate was 74.0%（20/27）.Conclusion：A high occurrence rate of IgA nephropathy was found in the young men in this area.The treatment with prednisone combined CTX can get approving response,but has a high half-year recurrence.

关 键 词：肾病综合征 IGA肾病 部队青年人 

分 类 号：R5[医药卫生—内科学]