1987年以来国外Ge-132生物学作用研究的新进展  

A Review of the biological Actions of Ge - 132 since 1987

作　　者：陈兆和 于占洋 

机构地区：[1]广州军区后勤部药物研究所,广州510500

出　　处：《广东微量元素科学》1999年第4期5-7,共3页Trace Elements Science

摘　　要：综述了Ｇｅ－１３２的生物学作用研究的新进展。包括：１．免疫调节作用，可增强强的松增高血浆超氧化物清除活性；抗癌抗艾滋病活性，能有效地缓解晚期癌症疼痛。２．对６０Ｃｏ照射白细胞生成超氧化物有保护作用，可刺激白细胞的基础Ｑ释放，防止ｏＣｏ照射白细胞Ｑ生成减少，在高浓度时具有膜稳定作用。３．防止白内障的发生。４．对抗白血病细胞的细胞毒作用。５．活化神经作用，有利于中风瘫患者的恢复。A review with 12 referrences is given on the biological actions of Ge - 132. Firstly, acting as an immunomodulator, Ce - 132 can promote prednisolone effects of superoxide scavenging activity of plas- ma in patients with immune disorders. It is efficient in treating and preventing AIDS and cancers. Ge- 132 also proves effective in relieving pain of terminal cancer patients.Secondly,Ge - 132 can stimulate the basal O2 released from leukocytes, prevent the decrease of O2- generation by 60Co - irradiated leuko- cytes and have a membrane stabilizing effect in higher concentration. Thirdly,Ge - 132 can delay sugar cataract formation.Forthly, it has the cytotoxic activity against P 388/DOX cells. And moreover, Ge- 132 injection will have the effectiveness to nerve function,so it is very userful for the rehabillitation of hemiplegia.

关 键 词：生物学作用 有机锗化合物 免疫调节作用 锗-132 

分 类 号：R977.5[医药卫生—药品] R977.9[医药卫生—药学]