一种简洁的(+)-新黄皮酰胺的全合成  

A Concise Total Synthesis of (+)-Neoclausenamide

作　　者：严兆华[1] 刘永杰[1] 田伟生[2] 康润华[1] 

机构地区：[1]南昌大学化学系,南昌330031 [2]中国科学院上海有机化学研究所,上海200032

出　　处：《有机化学》2010年第9期1387-1390,共4页Chinese Journal of Organic Chemistry

摘　　要：从化合物5出发,首先通过C-3位羟基的转位反应制得(+)-新黄皮酰胺(1)的前体化合物4,然后经过酮羰基的还原反应合成得到(+)-新黄皮酰胺(1).提供了一种简洁的(+)-新黄皮酰胺的全合成路线.考察了化合物5中C-3位羟基的转位反应的实验条件.（＋）-Neoclausenamide was successfully synthesized through a concise route which comprises the configuration inversion of C-3 hydroxy group in intermediate 5 and subsequent reduction of carbonyl group. The reaction conditions for the configuration inversion of C-3 hydroxy group were also investigated in detail.

关 键 词：(+)-新黄皮酰胺 全合成 转位反应 

分 类 号：R284[医药卫生—中药学]