无溶剂条件下固相合成2,3-二芳基-2,3-二氢喹唑啉-4(1H)-酮  

Synthesis of 2,3-Diaryl-2,3-dihydroquinazolin-4(1H)-one under Solvent-Free Conditions

作　　者：庄启亚[1] 付永春 唐丹[1] 查云赟[1] 荣良策[1] 屠树江[1] 

机构地区：[1]徐州师范大学化学化工学院,徐州221116 [2]河南商丘技师学院,商丘476000

出　　处：《有机化学》2010年第9期1405-1409,共5页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基础研究基金(No.08KJB150017)资助项目

摘　　要：在NaOH存在下,无溶剂加热靛红酸酐和席夫碱,合成一系列2,3-二芳基-2,3-二氢喹唑啉-4(1H)-酮衍生物.该反应产率高,操作简单.反应中考察了不同席夫碱对反应的适用性,合成了16个产物.产物结构经IR,1HNMR,HRMS确证.A series of 2,3-diaryl-2,3-dihydroquinazolin-4（1H）-one derivatives were synthesized from isatiocanhydride and Schiff base in the presence of sodium hydroxide under solvent-free conditions. The advantages of this procedure are simple protocol and high yields. Using different Schiff bases to prepare 2,3-diaryl-2,3-dihydroquinazolin-4（1H）-one derivatives,sixteen compounds were synthesized. The structures were determined by IR,1H NMR and HRMS techniques.

关 键 词：靛红酸酐 席夫碱 喹唑啉-4(1H)-酮 无溶剂合成 

分 类 号：TQ25[化学工程—有机化工]