阿替洛尔与醌茜素的荷移反应研究  

Study on the Charge Transfer Reaction Between Atenolol with Quinalizarin

作　　者：于丽丽[1] 李华侃[1] 赵桂芝[1] 

机构地区：[1]辽宁医学院化学教研室,辽宁锦州121001

出　　处：《分析科学学报》2010年第5期584-586,共3页Journal of Analytical Science

摘　　要：研究了阿替洛尔与醌茜素之间的荷移反应。阿替洛尔作为电子给体,醌茜素作为电子受体,两者在乙醇-水介质中反应生成荷移络合物。该络合物的λmax=568nm,表观摩尔吸光系数为7.91×103L.mol-1.cm-1,阿替洛尔药物质量浓度在0～30mg/L范围内服从比耳定律,相对标准偏差为0.92%(n=6)。应用本法测定了片剂中阿替洛尔的含量,回收率为98.9%～101.6%。The charge transfer reaction between atenolol and quinalizarin was studied.The determination was based on the formation of the charge transfer complex between atenolol（donor）and quinalizarin（acceptor forming）in alcohol-water solution with λmax at 568 nm and the apparent molar absorptivity of 7.91×103 L5mol-15cm-1.Beer＇s Law was obeyed in the range of 0~30 mg/L of atenolol and the relative standard deviation was 0.92%（n=6）.The proposed method is simple,rapid and accurate for determination of atenolol in tablets with the recovery of 98.9%~101.6%.

关 键 词：荷移反应 分光光度法 阿替洛尔 醌茜素 

分 类 号：O657.3[理学—分析化学]