Preparation of ozagrel-magnetoliposomes and investigation on the release in vitro under AC-magnetic field  

作　　者：刘彬 王君 

机构地区：[1]Department of Pharmacy,Liaoning University [2]Department of Chemistry,Liaoning University

出　　处：《渤海大学学报（自然科学版）》2010年第3期213-218,共6页Journal of Bohai University:Natural Science Edition

基　　金：国家自然科学基金项目(No:20371023);辽宁省教育厅自然科学基金资助项目(No:2008247)~~

摘　　要：To reduce the first-pass effect and increase the targeting of ozagrel(OZ),the ozagrel -magnetoliposomes(OZ-MLs)were prepared in this study.Here,we described the preparation and characterization of OZ-MLs.It had a diameter of around 0.2μm.To prevent the aggregation of particles,the magnetite was treated with a surfactant,resulting in a stable ferrofluid suspension. The cumulative release of OZ from OZ-MLs could be up to 64.5%in 30 min in vitro under AC-magnetic field.However,it was only 24.0%for OZ-MLs without AC-magnetic field.To reduce the first - pass effect and increase the targeting of ozagrel （ OZ）, the ozagrel -magnetoliposomes （OZ -MLs） were prepared in this study. Here, we described the prepara- tion and characterization of OZ - MLs. It had a diameter of around 0. 2 μm. To prevent the aggregation of particles, the magnetite was treated with a surfactant, resulting in a stable ferrofluid suspension. The cumulative release of OZ from OZ - MLs could be up to 64. 5 % in 30 min in vitro under AC - magnetic field. However, it was only 24. 0 % for OZ - MLs without AC - magnetic field.

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分 类 号：G353.23[文化科学—情报学] G232