大肠埃希菌Ⅰ类整合子与消毒剂抗性的研究  

Class Ⅰ Integron of Escherichia coli and Disinfectant Resistance

作　　者：李智山[1] 杨燕[1] 周乐翔[1] 赵建忠[1] 邓三季[1] 邹玖明[1] 

机构地区：[1]襄樊市中心医院临床检验部,湖北襄樊441021

出　　处：《中华医院感染学杂志》2010年第20期3103-3105,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院大肠埃希菌的Ⅰ类整合子遗传标记qacEΔ1-sul1基因存在状况。方法对临床分离的34株大肠埃希菌,采用PCR方法检测Ⅰ类整合子遗传标记qacEΔ1-sul1基因。结果 34株大肠埃希菌qacEΔ1-sul1基因阳性有28株(82.4%)。结论 34株大肠埃希菌药敏试验结果显示,β-内酰胺酶和氨基糖苷类抗菌药物耐药性高与Ⅰ类整合子遗传标记qacEΔ1-sul1基因高检出率有关。OBJECTIVE To investigate the class Ⅰ integron genetic marker（qacE△1-sul1 gene）of Escherichia coli.METHODS Thirty-four strains of E.coli were isolated from hospitalized patients,and the class Ⅰ integron genetic markers acE△1-sul1 gene）were analyzed by polymerase chain reaction.RESULTS Among thirty-four strains of E.coli,the qacE△1-sul1 gene expression was detected out in twenty-eight strains（82.4%）.CONCLUSION The high resistance of β-lactamantibiotics and aminoglycoside antibiotics are concerned with the high isolating rate of class Ⅰ integron genetic marker qacE△1-sul1 gene in ECO.

关 键 词：大肠埃希菌 整合子 基因 

分 类 号：R378.21[医药卫生—病原生物学]