抗菌药物使用继发酵母样真菌感染的调查与耐药性分析  

Antibacterial Drugs-induced Yeast-like Fungal Infections:Investigation and Analysis of Drug Resistance

作　　者：刘旗明 刘旗军[2] 叶瑞梅[2] 

机构地区：[1]衢州市柯城区人民医院检验科,浙江衢州324000 [2]衢州市常山县人民医院妇产科,浙江衢州324200

出　　处：《中华医院感染学杂志》2010年第19期3028-3029,共2页Chinese Journal of Nosocomiology

摘　　要：目的调查抗菌药物继发院内真菌感染的情况,以减少继发真菌感染的发生。方法对2007-2008年使用抗菌药的住院患者为试验组进行真菌培养,对照组为入院抗菌药物使用前的临床标本。结果应用抗菌药物继发真菌感染达35.5%,占同期真菌感染的80.9%,白色假丝酵母菌为主要致病菌,占59.8%;感染部位以呼吸道最多;药敏试验结果,两性霉素B敏感率85.1%;酮康唑敏感率最低,为54.0%,其他药物耐药性也有所增加。结论使用抗菌药物的住院患者酵母样真菌感染率高,与对照组比较有差异,出现了不同程度的耐药株,提示临床临床选用抗菌药物注意真菌继发感染,治疗真菌感染应以培养和药敏试验为依据。OBJECTIVE To investigate the antibacterial agents-induced nosocomial fungal infections,and to reduce the occurrence of secondary fungal infections.METHODS The clinical specimens collected from inpatients in 2007-2008 were divided into two groups：the test group was after antibacterials use and the control group was before antibacterials use and cultured for fungi.RESULTS The fungal infection rate in test group was up to 35.5%,accounting for 80.9% in the same period of fungal infection.Candida albicans were the major pathogen,accounting for 59.8%,the main infected site was upper respiratory tract,the sensitivity test inclicated that the sensitive rate to amphotericin B was 85.1%,to ketoconazole was the lowest,with 54.0% and the drug resistance to other antibiotics was increased.CONCLUSIONS The hospitalized patients after antimicrobial drugs have higher rates of yeast-like fungus infection,then the control group with statistical differences,there are varying degrees of drug-resistant strains detected,suggesting that the clinical use of antibiotics must control secondary fungal infections,and their treatment should be based on cultureing and sensitivity test.

关 键 词：抗菌药物 感染 酵母样真菌 药敏试验 

分 类 号：R978.1[医药卫生—药品]