复方肿瘤血管生成抑制因子口服液的一般毒性和遗传毒理研究  

A Study on the General Toxicity and Genotoxicity of Compound Oral Liquid of Tumor Angiogenesis Inhibitor

作　　者：向华[1,2] 杨保胜[1,2] 丰慧根 孙璐[1,2] 李永辉 徐存拴[1,2] 

机构地区：[1]河南师范大学生物系 [2]新乡医学院细胞生物学教研室

出　　处：《河南师范大学学报（自然科学版）》1999年第1期73-76,共4页Journal of Henan Normal University(Natural Science Edition)

基　　金：河南省杰出青年科学基金

摘　　要：为了探讨复方肿瘤血管生成抑制因子口服液（ＣＯＬ－ＴＡＩ）对动物及人体的一般毒性和遗传毒性，采用动物急性毒性试验、动物慢性毒性试验、小鼠骨髓嗜多染红细胞微核实验和人体外周血淋巴细胞体外培养染色体畸变实验，观察ＣＯＬ－ＴＡＩ的一般毒性和遗传毒性．结果显示：ＣＯＬ－ＴＡＩ对小鼠的急性毒性试验表明，该药口服途径的ＬＤ５０为９．１２０１ｇｋｇ－１（７．７６６ｇ～１０．７０９１ｇｋｇ－１）；慢性毒性试验显示该口服液对内脏各器官和生理指标均无任何蓄积毒性和延迟毒性反应作用；ＣＯＬ－ＴＡＩ对小鼠骨髓微核和人外周血淋巴细胞染色体畸变等均无诱变作用，ＣＯＬ－ＴＡＩ可降低环磷酰胺（ＣＴＸ）对受试动物细胞微核的发生率．ＣＯＬ－ＴＡＩ无毒，对化学法突变剂引起的微核产生有抑制作用，对染色体损伤有一定的保护作用．To research the general toxicity and genotoxicity of compoand oral liquid of Tumor Angiogenesis inhibitor (COL-TAI)on experimental animal and human, cute and chronic toxicity in rice,bone marrowmicronucleus text in mice and lymphocyte chromosomal aberration text in human beings were determined. The results showed that acute toxicitial test results show that this oral liquid's LD50 were 9.1201g·kg -1 , chronic toxicitial test show that it had no toxicity. Genotoxitial test results show that this oral liquid did not raise eighter rate of micronucleus orchromosomal aberration. It could reduce the rate of mocronucleus was induced by CTX and chromosomal aberration. COL-TAI has no general toxicity and genotoxicity,It could reduced the rate of chromosomal aberration.

关 键 词：毒性试验 COL-TAI 消癌露 抗癌药 遗传毒性 

分 类 号：R979.1[医药卫生—药品] R965.3[医药卫生—药学]