乙肝感染产妇与新生儿乙肝血清标志物检测结果分析  

HEPATITIS B INFECTION IN PREGNANT WOMEN AND NEONATAL HEPATITIS B MARKERS DETECTION

作　　者：胥庆梅 

机构地区：[1]成都崇州妇幼保健院,崇州611230

出　　处：《现代预防医学》2010年第20期3858-3859,3864,共3页Modern Preventive Medicine

摘　　要：[目的]进一步了解本市乙肝血清标志物(HBV-M)阳性产妇与其新生儿HBV宫内感染状况,为有效阻断HBV母婴传播提供依据。[方法]回顾性调查本院336例HBV-M阳性(除单项抗-HBs阳性)产妇及其新生儿,根据传染性强弱将产妇模式分为3组,比较各模式组对新生儿HBV-M的影响进行分析。[结果]①产妇与新生儿HBV-M模式类型有差别,新生儿出现了临床上少见抗-HBs、HBeAg、抗-HBc圴阳性和HBeAg、抗-HBc圴阳性模式。②HBsAg阳性产妇的新生儿宫内感染率为10.2%,其HBV-M阳性率(除单项抗-HBs阳性外)为97.3%,其中HBsAg、HBeAg、抗-HBc均阳性(大三阳)产妇的新生儿宫内感染率达35.0%(14/40),HBV-M阳性率92.5%(37/40),且以HBeAg阳性为主。③HBsAg和HBeAg均阴性产妇的新生儿宫内感染率为0.5%,HBV-M阳性率为88.4%,并以产妇相同模式出现最多。[结论]本市HBsAg阳性特别是伴有HBeAg阳性产妇发生HBV宫内感染率较高,为高危因素,而HBsAg阴性产妇的新生儿HBV-M阳性率也较高,对HBV宫内传播的风险不可低估。[Objective] To understand the situation of the infection rate between hepatitis B virus markers（HBV-M） positive maternal and hepatitis B virus（HBV） neonatal intrauterine in our city,and provide evidences to cut off the infective access from mother to baby effectively.[Methods] Retrospective investigation was performed on 336 HBV-M positive pregnant women and infants in our hospital,and the pregnant women were divided into three groups based on the infectious level.Then we compared the different infectious levels on the HBV-M.[Results] ① The types of HBV-M between mother and neonate showed to be difference,for example：positive Anti-HBS,HBeAg and Anti-HBC,and positive HBeAg and anti-HBc presented among neonate which rarely occurred in clinical;② The infection rate of neonate born from HBsAg-positive puerperae was 10.2%,meanwhile,the HBV-M-positive（except the single Anti-HBS） rate was 97.3%.Among them,the rate was 35.0%（14/40） caused by HBsAg,HBeAg and Anti-HBc pregnant,then the rate of HBV-M positive was 92.5%（37/40）,which mainly included HBeAg-positive.③ The ratio of infected infants whose mother were HBsAg-negative was only 0.5%,however,the positive reached to 88.4%.Furthermore,the same pattern of the puerperae appeared to be most.[Conclusion] The survey indicated that HBsAg-positive with HBeAg-positive would result in high infective risk of intrauterine,at the same time,there also be a high rate with HBsAg-negative so that we shouldn＇t under-estimate the risk of HBV＇s spread in intrauterine.

关 键 词：乙型肝炎病毒(HBV) 乙肝病毒血清标志物(HBV-M) 宫内感染 

分 类 号：R512.62[医药卫生—内科学]