电针不同穴位治疗急性脑缺血再灌注大鼠疗效观察  

Therapeutic Effects of Electroacupuncture at Different Acupoints in Treating Acute Cerebral Ischemia Reperfusion in Rats

作　　者：彭拥军[1] 陈理[1] 王和生[1] 周飞[2] 郭景春[2] 

机构地区：[1]江苏省中医院针灸康复科,江苏南京210029 [2]复旦大学上海医学院神经生物学国家重点实验室,上海200032

出　　处：《安徽中医学院学报》2010年第5期31-34,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：上海市科委科研计划项目(03DZ19954-1);国家自然科学基金项目(81001556)

摘　　要：目的观察电针不同穴位对急性脑缺血再灌注大鼠的疗效。方法选用健康SD雄性大鼠46只,阻塞大鼠大脑中动脉,复制急性脑缺血再灌注模型,分为正常对照组、模型组和电针组,电针组又分为6组不同穴位。采用神经功能缺损评分、局部脑血流和脑梗死体积测定分别观察大鼠神经功能缺损程度及脑梗死体积变化。结果脑缺血再灌注24 h后,电针"人中、百会"和"曲池、内关"对急性脑缺血具有良好的效果,而电针其他组穴位疗效较差。结论电针治疗急性脑缺血具有穴位特异性。Objective To investigate the efficacy of electroacupuncture （EA） at different acupoints in treating acute cerebral ischemia reperfusion （CIR） in rats. Methods A total of 46 healthy male SD rats were employed to induce acute CIR rat model using middle cerebral artery occlusion. They were randomly divided into normal control group, model group and EA group, and the rats in EA group were subdivided into six group treated with EA at different acupoints, respectively. The changes of neurological impairment scores and cerebral infarction volume were observed by neurological impairment scoring, the detection of regional cerebral blood flow and cerebral infarction volume, respectively. Results Therapeutic effects of EA at Renzhong and Baihui acupoints were superior to those of EA at Quchi and Neiguan acupoints after 1 hour of cerebral ischemia following 24 hours of reperfusion. Conclusion EA has relative aeupoint specificity in treating acute cerebral ischemia.

关 键 词：脑缺血再灌注 电针 穴位特异性 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R246[医药卫生—临床医学]