驻极体美洛昔康贴剂对大鼠血液和肝脏组织中药物浓度的影响  

Effect of Electret Meloxicam Patch on the Drug Concentration in Plasma and Liver of SD Rats

作　　者：肖永恒[1] 江键[2] 李国栋[1] 王冬[1] 涂晔[1] 马琳[2] 梁媛媛[2] 崔黎丽[1] 

机构地区：[1]第二军医大学药学院,上海200433 [2]第二军医大学基础部,上海200433

出　　处：《河北大学学报（自然科学版）》2010年第5期560-563,共4页Journal of Hebei University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(50577066;50977089);军队"十一五"国际合作项目(06H022)

摘　　要：利用药剂学方法和栅控恒压电晕充电技术制备驻极体美洛昔康贴剂,考察驻极体美洛昔康贴剂经皮给药24 h内,美洛昔康在SD大鼠血液和肝脏组织中浓度的变化,探讨负极性驻极体对美洛昔康的透皮促渗效果.实验结果表明经皮给药24 h内,-2 000 V驻极体对美洛昔康的透皮促渗效果不明显;-1 200 V驻极体对美洛昔康的透皮吸收有明显的促渗作用,且促渗倍数为对照组4倍.PP electret meloxicam patches were prepared by the corona charging and pharmaceutical method to study the concentration changes of drug in plasma and liver tissue within 24h after transdermal administration,and to investigate the enhancement of negative electret on transdermal absorption of meloxicam.The results indicated that-1 200 V electret had a remarkable enhancing effect on percutaneous absorption of meloxicam with the enhancing ratio of 4,but-2 000 V electret showed no obvious enhancement on meloxicam transdermal absorption.Therefore,-1 200 had much better enhancing effect on meloxicam transdermal absorption as compared with-2 000 V electret.

关 键 词：经皮给药 驻极体 美洛昔康 血药浓度 肝脏组织 

分 类 号：O484[理学—固体物理]